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Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With Neuroblastoma

Neuroblastoma Clinical Trial

Official title:
A Pilot Study of Imetelstat Given Intravenously on Day 1 and 8 of a 21 Day Schedule Alone and With Standard 13-Cis-Retinoic Acid in Children With Recurrent and/or Refractory Neuroblastoma

Clinical Trial Summary

The purpose of this study is to determine the best dose of imetelstat when given alone for patients with neuroblastoma and also when given in combination with 13-cis-retinoic acid.

Clinical Trial Description

This research is being done because imetelstat has been shown to slow the growth of tumours in animals and may also be doing so in adults, but we are not sure if it can also slow tumour growth in children and offer better results than standard treatment. Laboratory studies suggest imetelstat may increase the activity of 13-cis-retinoic acid, which is used to treat neuroblastoma, although this is not yet proven in patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01916187
Study type Interventional
Source Canadian Cancer Trials Group
Contact
Status Withdrawn
Phase Phase 1
Start date July 30, 2013
Completion date January 16, 2014
View Details
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