Neuroblastoma Clinical Trial
Official title:
Prognostic Impact of Segmental Chromosome Aberrations in Non MYCN Amplified Neuroblastomas in Different Age Groups
This research studies chromosomes in samples from younger patients with neuroblastoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
OBJECTIVES:
I. Determine the impact on overall survival of patients with non-MYCN neuroblastoma below 18
months of age as compared to neuroblastoma patients above 18 months of age.
OUTLINE:
Archived DNA samples are analyzed for segmental chromosome aberrations by multiplex
ligation-dependent probe amplification (MLPA), a polymerase chain reaction (PCR)-based
technique. The following genomic regions are being studied: 1p, 1q, 3p, 4p, 7q, 9p, 11q, and
17q, as are the copy numbers of MYCN, NAG, DDX1, and ALK genes.
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Observational Model: Cohort, Time Perspective: Retrospective
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