Neuroblastoma Clinical Trial
Official title:
Proposed Studies on the Role of Growth Factor Receptor Trafficking in Neuroblastoma Pathogenesis
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This research trial studies biomarkers in tumor samples from younger patients with
neuroblastoma.
OBJECTIVES:
- To determine the expression of UBE4B, hrs, and members of the ubiquitination protein
complex in previously banked primary neuroblastoma tumor samples from the Children's
Oncology Group.
- To determine the correlation of expression levels and cellular localization of the
UBE4B and hrs proteins with growth factor-receptor tumor cell-surface expression.
- To determine the 1p36 deletion status by fluorescence in situ hybridization (FISH)
analysis and their association with expression levels of UBE4B and hrs in previously
banked primary neuroblastoma tumor samples from the Children's Oncology Group.
OUTLINE: Banked tumor tissue samples are analyzed for expression of UBE4B, hrs, members of
the ubiquitination protein complex, growth factor receptors, and 1p36 deletion status by
immunohistochemistry (IHC), fluorescent microscopy, and fluorescence in situ hybridization
(FISH).
;
Observational Model: Case-Only, Time Perspective: Retrospective
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