Sleep Clinical Trial
Official title:
Hangover, Congeners, Sleep and Occupational Performance
The objective is to investigate residual effects of heavy drinking, with or without hangover
symptoms. The primary aim is to test several hypotheses about residual effects of heavy
drinking. Hypotheses about how heavy drinking affects next-day performance include direct
physiological effects of alcohol, alcohol withdrawal effects, and non-ethanol effects, such
as congeners, or family history of alcohol problems. The investigators will test the
following hypotheses:
1. relative to placebo, heavy drinking will degrade next-day performance, and this
relationship will be mediated in full or in part by quality of sleep;
2. a high congener alcoholic beverage will affect performance to a greater degree than a
low congener beverage and this relationship will be mediated by severity of hangover
symptoms.
The primary aim of the proposed study is to test several hypotheses about residual effects
of heavy drinking. Hypotheses about how heavy drinking affects next-day performance include
direct physiological effects of alcohol (e.g., electrolyte imbalance, low blood sugar, sleep
disturbance), alcohol withdrawal effects, acetaldehyde toxicity, and non-ethanol effects,
such as congeners or family history of alcohol (Swift and Davidson, 1998). Using a
placebo-controlled randomized trial, we will dose participants with placebo or with a high
or low congener alcoholic beverage (to a level of 0.10 g% BAC) the night before they perform
exercises on a neurobehavioral evaluation system. We will monitor participants’ sleep to
assess sleep disturbance. We will collect information on hangover symptoms the morning after
dosing. We will also collect data on participants’ family history of drinking problems. We
will test the following hypotheses:
1. relative to placebo, heavy drinking will degrade next-day cognitive performance, and
this relationship will be mediated in full or in part by quality of sleep; and
2. a high congener alcoholic beverage will affect performance to a greater degree than a
low congener beverage and this relationship will be mediated by severity of hangover
symptoms.
We will explore whether the residual effects of heavy drinking on next-day cognitive
performance are attenuated among participants positive for a family history of alcohol
problems, relative to family-history-negative participants.
A secondary aim is to test the effectiveness of the Psychomotor Vigilance Test (PVT), a
validated measure of fatigue, as a fitness-for-duty test. We will test whether the PVT can
distinguish dosing status (alcohol or placebo) of participants at the time performance is
measured the next day and the extent to which PVT measures correlate with performance
scores.
Participants will be young adults ages 21-30 who are currently enrolled in an undergraduate
college or university or have graduated from a college or university. Alcoholic beverages
will be bourbon (high-congener) in soda or vodka (low-congener) in soda. Placebo will be
tonic alone. We will use a mixed within- and between-subjects design, balancing the order of
placebo and alcohol administration. Performance will be measured using a computer-based
neurobehavioral evaluation system.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Prevention
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04044495 -
Sleep, Rhythms and Risk of Alzheimer's Disease
|
N/A | |
Recruiting |
NCT06079853 -
Nurse Suicide: Physiologic Sleep Health Promotion Trial
|
N/A | |
Completed |
NCT05017974 -
Research on Improving Sleep During Pregnancy
|
N/A | |
Recruiting |
NCT05206747 -
Ottawa Sunglasses at Night for Mania Study
|
N/A | |
Enrolling by invitation |
NCT04253054 -
Chinese Multi-provincial Cohort Study-Beijing Project
|
||
Completed |
NCT04513743 -
Ultra Long-Term Sleep Monitoring Using UNEEG™ Medical 24/7 EEG™ SubQ
|
N/A | |
Completed |
NCT03251274 -
Bath Machine on Sleep Quality in Nursing Home
|
N/A | |
Completed |
NCT04102345 -
Lavender vs Zolpidem Sleep Quality During Diagnostic PSG
|
Early Phase 1 | |
Completed |
NCT03725943 -
Comparison of Dreem to Clinical PSG for Sleep Monitoring in Healthy Adults
|
N/A | |
Active, not recruiting |
NCT05062161 -
Sleep Duration and Blood Pressure During Sleep
|
N/A | |
Completed |
NCT04562181 -
Consistency Evaluation of the qCON, qNOX Indices and Bispectral Index
|
N/A | |
Completed |
NCT05576844 -
Ai Youmian (Love Better Sleep) for People Living With HIV
|
N/A | |
Completed |
NCT05102565 -
A Dyadic Telehealth Program for Alzheimer's Patients/Caregivers
|
N/A | |
Completed |
NCT04688099 -
Synovial Fluid Sleep Study
|
||
Recruiting |
NCT04171245 -
Prescribing Laughter for Sleep and Wellbeing in UAE University Students
|
N/A | |
Completed |
NCT03758768 -
The Effects of a Blue Monochromatic Light Intervention on Evening-type Individuals' Sleep and Circadian Rhythms
|
N/A | |
Completed |
NCT03163498 -
Evaluation of Sleep Pattern and Mood Profile in Hypertensive Patients
|
||
Completed |
NCT04093271 -
Investigating the Efficacy of Rest-ZZZ Formula in Healthy Participants With Difficulty Falling Asleep or Staying a Sleep
|
Phase 1 | |
Completed |
NCT03673397 -
The Acute Effect of Aerobic Exercise on Sleep in Patients With Depression
|
N/A | |
Completed |
NCT04120363 -
Trial of Testosterone Undecanoate for Optimizing Performance During Military Operations
|
Phase 4 |