Clinical Trials Logo

Clinical Trial Summary

Resting-state functional magnetic resonance imaging (RS-fMRI) has frequently been used to investigate local spontaneous brain activity in Parkinson's disease (PD) in a whole-brain, voxel-wise manner. To quantitatively integrate these studies, we conducted a coordinate-based meta-analysis on 15 studies that used amplitude of low frequency fluctuation (ALFF) and 11 studies that used regional homogeneity (ReHo). All these ALFF and ReHo studies have compared PD patients with healthy controls. We also performed a validation RS-fMRI study of ALFF and ReHo in a frequency-dependent manner for a novel dataset consisting of PD and healthy controls.


Clinical Trial Description

Seed-based d Mapping (formerly Signed Differential Mapping, SDM) software (version 5.141 for Windows) (www.sdmproject.com) was used for meta-analysis.

For the validation, fMRI data were acquired on a 3 Tesla Magnetic Resonance scanner (Trio system; Siemens Magnetom scanner, Erlangen, Germany) with gradient-echo echo-plannar imaging sequences. Whole brain fMRI scanning was carried out. All participants were instructed to keep their eyes closed, relax, remain motionless, not think of anything in particular, and not fall asleep. Foam pads were used to minimize head motion. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03439163
Study type Observational
Source Xuanwu Hospital, Beijing
Contact
Status Completed
Phase N/A
Start date May 2011
Completion date January 2016

See also
  Status Clinical Trial Phase
Active, not recruiting NCT05586750 - Statins in Reducing Events in the Elderly Mind (STAREE-Mind) Imaging Substudy Phase 4
Completed NCT04050800 - Carbon-11 Butanol: Whole Body Radiochemical and Radiation Safety Early Phase 1
Recruiting NCT04863859 - Persons With Dementia and Their Extended Family Caregivers
Recruiting NCT05655650 - Identifying Biomarkers in Alzheimer's Disease
Completed NCT04937127 - Efficiency of E-learning and Role-playing for the Training of Nursing Home Caregivers in the Support of Agitation in Neurodegenerative Diseases
Enrolling by invitation NCT03197363 - BiaƂystok PLUS - Polish Longitudinal University Study
Enrolling by invitation NCT03322306 - Establishment of Genetic Basis for Neurological Disease by Genetic Screening
Withdrawn NCT05921929 - First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM) Phase 1
Recruiting NCT05209698 - Self-Management Behaviors of Arabs and Jews With Parkinson's Disease and Their Associations With Health Outcomes
Completed NCT04362228 - The Effects of Whole-body Exercise to Improve Swallowing Function in Older Adults With Dementia N/A
Enrolling by invitation NCT05008094 - The Epidemiology of Parkinson's Disease in Croatia and the Influence of Genetic Factors and Microbiota on the Progression and Treatment Outcomes of the Disease (GiOPARK)
Completed NCT03279991 - Neuromed- Integrated Health Life Platform and Biobank
Active, not recruiting NCT04228653 - Long-Term Follow-up Safety After DDS Implantation With/Without CDNF Infusions Phase 1/Phase 2
Recruiting NCT05328492 - Volume Mode Non-invasive Ventilation in Amyotrophic Lateral Sclerosis N/A
Not yet recruiting NCT06151600 - A Prospective Natural History and Outcome Measure Discovery Study of Charcot-Marie-Tooth Disease, Type 4J
Recruiting NCT04880356 - Longitudinal Study of Ultra-rare Inherited Metabolic and Degenerative Neurological Diseases.
Active, not recruiting NCT03609125 - Cord Blood Serum in the Treatment of Neuro-Degenerative Ophthalmic Diseases. 1-Glaucoma N/A
Recruiting NCT03153670 - 3T MRI in Patients With Deep Brain Stimulation (DBS) N/A
Completed NCT03775538 - Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease. Extension to HP-CD-CL-2002 Clinical Study Phase 1/Phase 2
Enrolling by invitation NCT04635540 - Decreased Empathy and Emotion Recognition in Patients With Neurodegenerative Disease N/A