Symptom Based Treatment of Neuropathic Pain

Spinal Cord Injury Clinical Trial

Official title: Symptom-Based Treatment for Neuropathic Pain in Spinal Cord Injured Patients, Randomized Clinical Trial

Status Completed

Clinical Trial Summary

1. Neuropathic pain in spinal cord injured patients

1. Inclusion criteria

• pain intensity, visual analogue scale > 3

• a LANSS (Leeds assessment of neuropathic symptoms and signs) score of 12 and above

• aged ≥20

2. Method

• Stop pain medications

• Test oxcarbazepine (150mg twice daily) and pregabalin (150mg twice daily)

• Check pain intensity (VAS score) with Baron's classification

Clinical Trial Description

In the present study, pharmacologic treatment included pregabalin and oxcarbazepine.

Stop medications such as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), tramadol and anti-spastic drugs (baclofen, tizanidine) and other medications known to have effect on pain and the central nervous system prior to the study for at least 3 days.

1. Pain intensity (VAS score)

1. 4 spontaneous characters

• electric

• burning

• pricking

• numbness

2. evoked pain

• allodynia

• heat hyperalgesia

• pressure hyperalgesia

2. Location of neuropathic pain

1. neuropathic pain at level of spinal cord injury

2. neuropathic pain below level of spinal cord injury

2. Side effects ;

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Neuralgia
• Spinal Cord Injuries
• Spinal Cord Injury

• NCT number: NCT02180880
• Study type: Interventional
• Source: CHA University
• Status: Completed
• Phase: Phase 4
• Start date: November 2012
• Completion date: August 2014