Imbalance of Constituents of Food Intake Clinical Trial
Official title:
Dietary Intervention of Stress-Induced Neurovegetative Disorders in Men and Women With a Specific Amino Acid Composition With Micronutrients
Psychosocial stress leads to altered neuroendocrine functions, such as serotonergic
dysfunction, as well as alterations of the autonomic nervous system and the
hypothalamic-pituitary-adrenal (HPA) axis activity resulting in an imbalance between
inhibitory and excitatory neurotransmitters. Clinical consequences include, inter alia,
neurovegetative disorders, higher resting heart rate, hypertension, depressive symptoms,
sleep disturbances, irregular body-weight changes, and insulin resistance. Poor dietary
intake of the essential amino acid L-tryptophane as a precursor to 5-hydroxytryptamine (HT,
serotonin) increases sensitivity to stress.
It is therefore the investigators hypothesis that daily oral administration of an amino acid
mixture (dosage 3.8 g/day) with micronutrients specifically designed to decrease
neurovegetative disorders will target these neuroendocrine and metabolic alterations in
adults with psychosocial stress. The principal endpoints will be a decrease in points in the
psychological-neurological questionnaire (PNF).
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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