Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Intercostal Nerve Block for Chronic Post-thoracotomy Pain

Nerve Block Clinical Trial

Official title:

Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Slit Intercostals Nerve Block for Chronic Post-thoracotomy Pain:A Single Blind Randomized Control Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05556122
• Other study ID #: 2022-K107-01
• Status: Recruiting
• Phase: N/A
• Start date: July 4, 2022
• Est. completion date: December 30, 2022

Study information

• Verified date: September 2022
• Source: Affiliated Hospital of Nantong University
• Contact: YiBin Qin
• Phone: 13815212600
• Email: 572537172[@]qq.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The patients were divided into two groups by random number method: GroupRD1 group and GroupRD2 group were given general anesthesia and intercostal nerve block.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml.

Description:

The RD1 group received ultrasound-guided intercostal nerve block at the incision before anesthesia induction, and the RD2 group received ultrasound-guided intercostal nerve block at the lateral costal Angle before anesthesia induction.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: December 30, 2022
• Est. primary completion date: December 30, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

1. 18-70 years old

2. ASA grade I-III

3. BMI: 18.5-28kg/m2

4. Type of surgery: elective thoracoscopic lung mass resection

5. Informed consent has been signed by the patient and/or family members

Exclusion Criteria:

1. game anesthesia or sugar cortical hormone drugs allergic

2. preoperative use of opioid medicines

3. serious blood coagulation dysfunction

4. serious heart, lung, liver and renal insufficiency

5. put, chemotherapy, and glucocorticoid immunosuppressive therapy history or diseases of the immune system

6. peptic ulcer

7. newly gastrointestinal surgery

8. has a history of thoracic surgery

9. is the central nervous system disease

10. Other glucocorticoids should be used with caution in patients such as fractures, wound repair, corneal ulcers, hyperadrenocortical disease, diabetes mellitus, pregnant women, etc.

Related Conditions & MeSH terms

• Nerve Block

Intervention

Other:
• intercostal nerve block
General anesthesia and intercostal nerve block were performed. The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml
• lateral intercostal nerve block
lateral intercostal nerve block

Drug:
• ropivacaine + compound betamethasone
The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml

Locations

Country	Name	City	State
China	YiBinQin	Nantong	Jiangsu

Sponsors (1)

Lead Sponsor	Collaborator
Affiliated Hospital of Nantong University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Acute and chronic postoperative pain	Numeric rating scale(NRS) is used to assess acute postoperative pain	6 hours after surgery
Primary	Acute and chronic postoperative pain	Numeric rating scale(NRS) is used to assess acute postoperative pain	24 hours after surgery
Primary	Acute and chronic postoperative pain	Numeric rating scale(NRS) is used to assess acute postoperative pain	48 hours after surgery
Primary	Acute and chronic postoperative pain	Numeric rating scale(NRS) is used to assess acute postoperative pain	1 months after surgery
Primary	Acute and chronic postoperative pain	Numeric rating scale(NRS) is used to assess acute postoperative pain	3 months after surgery