Nephropathy Clinical Trial
Official title:
Effect of Intravenous Sodium Chloride on Urinary Biomarkers for Measurement of Sodium- and Water Channel Activity in the Nephron in Healthy Subject an Patients With Chronic Kidney Disease. A Case Control Study
Patients with chronic kidney disease (CKD) have a defect in the tubular reabsorption of
sodium, and therefore the ability to excrete a sodium load is diminished compared to healthy
subjects.
Urinary biomarkers reflects the water- and sodium-channel activity in the kidney and may be
measured after an infusion with hypertonic saline in CKD patients and healthy subjects.
The fractional sodium excretion is elevated as high as 10-20% In patients with chronic
kidney disease (CKD) Changes in the sodium intake results in a slower expansion and/or
reduction in extracellular fluid in CKD patients.
Urinary biomarkers reflects the kidneys transport of sodium and water in the nephron.
Changes in the sodium-and water channel activity is induced by intervention with hypertonic
Saline (3.0%) The change in sodium-and water channel activity is followed by change in
extracellular and intracellular fluid compartments and the plasma concentration of
vasoactive hormones.
The purpose of this study is to investigate the changes in urinary biomarkers (u-NKCC2,
u-ENaC-gamma and u-AQP2), the activity of the sodium-and water channels, the extra- and
intracellular fluid compartments and the plasma concentration of Vasoactive hormones in
patients with CKD and in healthy subjects.
Subjects and patients are examined during one examination day. Four days prior to the
examination day the subjects consume a standardized diet based on the amount of sodium and
calories. On the examination day the subjects receive an infusion with hypertonic saline.
Renal function is measured by renal clearance of 51Cr-EDTA. Urinary biomarkers (u-NKCC2,
u-ENaC-gamma and u-AQP2) are measured to evaluate the activity of sodium channels in the
nephron and changes in fluid compartments are measured by body composition monitor.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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