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Clinical Trial Summary

Leflunomide versus Azathioprine for Maintenance Therapy of Lupus Nephritis


Clinical Trial Description

Proliferative glomerulonephritis is a common and severe manifestation of systemic lupus erythematosus (SLE) that usually requires intensive therapy with high doses of glucocorticosteroids and cytotoxic drugs, such as intravenous (IV) cyclophosphamide (CYC). The objective of this Trial is to compare leflunomide (LEF) and azathioprine (AZA), in terms of efficacy and toxicity, as remission-maintaining treatment of proliferative lupus glomerulonephritis, after a remission-inducing therapy with a short-course IV CYC regimen. The hypothesis of this trial is that LEF is non-inferior to AZA. ;


Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01172002
Study type Interventional
Source RenJi Hospital
Contact Bao Chun De
Phone 086-02158752345
Email baochunde_1678@yahoo.com.cn
Status Recruiting
Phase N/A
Start date March 2010

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