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Neoplasms, Plasma Cell clinical trials

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NCT ID: NCT04466475 Withdrawn - Plasma Cell Myeloma Clinical Trials

Radioimmunotherapy (211At-OKT10-B10) and Chemotherapy (Melphalan) Before Stem Cell Transplantation for the Treatment of Multiple Myeloma

Start date: January 27, 2024
Phase: Phase 1
Study type: Interventional

This phase I trial studies the side effects and best dose of 211At-OKT10-B10 when given together with melphalan before a stem cell transplantation in treating patients with multiple myeloma. The radioimmunotherapy drug 211At-OKT10-B10 is a monoclonal antibody, called OKT10-B10, linked to a radioactive substance called 211At. OKT10-B10 attaches to CD38 positive cancer cells in a targeted way and delivers 211At to kill them. Drugs used in chemotherapy, such as melphalan, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving 211At-OKT10-B10 with melphalan before a stem cell transplant may kill more cancer cells.

NCT ID: NCT04439305 Withdrawn - Clinical trials for Hematopoietic and Lymphoid Cell Neoplasm

Testing Dasatinib as a Potential Targeted Treatment in Cancers With DDR2 Genetic Changes (MATCH-Subprotocol X)

Start date: February 25, 2016
Phase: Phase 2
Study type: Interventional

This phase II MATCH treatment trial identifies the effects of dasatinib in patients whose cancer has a genetic change called DDR2 mutation. Dasatinib may block proteins called tyrosine kinases, which may be needed for cancer cell growth. Researchers hope to learn if dasatinib will shrink this type of cancer or stop its growth.

NCT ID: NCT04392648 Withdrawn - Clinical trials for Relapsed and/or Refractory Multiple Myeloma

A Study to Evaluate the Safety, Tolerability and Efficacy of Intravenous TAK-573 as Part of Combination Therapy in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Start date: June 24, 2020
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the safety, tolerability, and recommended phase 2 dose (RP2D) of TAK-573 when used with dexamethasone and in combination with bortezomib, pomalidomide, or cyclophosphamide, in participants with RRMM.

NCT ID: NCT04361851 Withdrawn - Multiple Myeloma Clinical Trials

Study of Dara-Pembro for Multiple Myeloma Patients

Start date: June 9, 2021
Phase: Phase 2
Study type: Interventional

This is a phase II, single-arm, open-label study in subjects with relapsed and/or refractory multiple myeloma (RRMM) comparing Pembrolizumab (Pembro) in combination with Daratumumab (Dara) to the historical control of Daratumumab.

NCT ID: NCT04355039 Withdrawn - Clinical trials for Refractory Multiple Myeloma

INCB053914 and Pomalidomide With Dexamethasone for Relapsed and/or Refractory Multiple Myeloma

Start date: July 1, 2021
Phase: Phase 1
Study type: Interventional

This is a prospective, single-center, open-label phase Ib study aimed at determining a recommended phase II dose of INCB053914 and pomalidomide with dexamethasone. The trial will follow a 3 + 3 phase I dose-escalation design.

NCT ID: NCT04348006 Withdrawn - Clinical trials for Newly Diagnosed Multiple Myeloma

Assessment of Bortezomib (Alvocade ®) Efficacy and Safety in Newly Diagnosed Multiple Myeloma Patients

MM
Start date: March 1, 2020
Phase: Phase 4
Study type: Interventional

Bortezomib considered the standard of care for treating multiple myeloma patients, the aim was to assess the safety and efficacy of newly approved drug (Alvocade ®) in Iraq, in newly diagnosed patients.

NCT ID: NCT04288765 Withdrawn - Multiple Myeloma Clinical Trials

Carfilzomib, Daratumumab, Lenalidomide and Dexamethasone as First Line Treatment in Multiple Myeloma

Start date: March 1, 2020
Phase: Phase 3
Study type: Interventional

Carfilzomib in combination with lenalidomide, daratumumab and dexamethasone (KRDd) can induce profound clinical responses. The investigators want to observe the effectiveness of the quadruple therapy of carfilzomib, lenalidomide, daratumumab and dexamethasone on patients receiving 8 cycles of KRDd with autologous stem cell transplantation versus patients with 8 cycles of KRDd without autologous stem cell transplantation.

NCT ID: NCT04258683 Withdrawn - Multiple Myeloma Clinical Trials

A Study of Pembrolizumab Added to the Standard First-Line Therapy of Cyclophosphamide, Bortezomib, and Dexamethasone (CyBorD) for NDMM NTE

Start date: February 17, 2021
Phase: Phase 2
Study type: Interventional

This is a phase 2A multi-centre, open label, pilot study of pembrolizumab added to the standard first-line therapy of cyclophosphamide, bortezomib and dexamethasone (CyBorD) in newly diagnosed patients with multiple myeloma that are not eligible for autologous stem cell transplantation.

NCT ID: NCT04230031 Withdrawn - Multiple Myeloma Clinical Trials

Phase II Study of Daratumumab Pre-Mobilization and Post-ASCT in Multiple Myeloma

Start date: July 2, 2021
Phase: Phase 2
Study type: Interventional

This study will use the drug daratumumab in patients who did not achieve at least a very good partial response (VGPR) and are already planned to have an Autologous Stem Cell Transplant (ASCT). Daratumumab will be given before the stem cell collection to attempt to get rid of any multiple myeloma cells that may be present in the stem cell collection and after the ASCT to get rid of any multiple myeloma cells that may be remaining.

NCT ID: NCT04223661 Withdrawn - Multiple Myeloma Clinical Trials

Frailty Score-guided Dosing of Lenalidomide, Dexamethasone and Daratumumab Induction Therapy

Start date: December 6, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine if using a subject's baseline frailty score to guide the dosing of lenalidomide in a combination with dexamethasone and daratumumab (DRd lite).