Neoplasms, Gastrointestinal Clinical Trial
Official title:
The Role of ctDNA, PVT1 and ROS in Diagnosis and Treatment of Gastrointestinal and Hepatobiliary Pancreatic Cancer
This study aims to evaluate the role of ct-DNA, PVT1 and reactive oxygen species (ROS) as biomarkers in the diagnosis, treatment and recurrence monitoring of gastrointestinal and hepatobiliary pancreatic cancer.
Epidemiological surveys showed a significant increasing trend of gastrointestinal and
hepatobiliary pancreatic cancer in recent years. How can make an early diagnosis of
gastrointestinal and liver cancer as well as prognostic evaluation and efficacy monitoring,
has become the hotspot. "liquid biopsy", which is meant to detect cancers by sequencing the
DNA in a few drops of a person's blood. It may detect cancers early, even before symptoms
arise, when there is just a few cells in the blood circulation.
ct-DNA in cancer patients often bears similar genetic and epigenetic features to the related
tumor DNA. There is evidence that some of the ct-DNA originates from tumoral tissue.
Besides, ct-DNA can easily be isolated from the circulation and other body fluids of
patients, makes it a promising candidate as a non-invasive biomarker of cancer.
It is known that levels of cellular ROS correlate with the aggressiveness of tumour cells
and prognosis of patients. Cancer cells with increased endogenous ROS stress are more
sensitive to anticancer agents and high levels of ROS generated by chemotherapeutic agents
can induce cell death. Hence, ROS levels before and after chemotherapy in cancer cells can
be an early indicator of treatment efficacy, which has the potential to shed new light on
the choice of cancer therapy.
This study aims to evaluate the role of ct-DNA and ROS as biomarkers in the diagnosis,
treatment and recurrence monitoring of gastrointestinal and hepatobiliary pancreatic cancer.
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