Optimizing Antibiotic Use in Neonatal Intensive Care Units in China

Neonates Clinical Trial

Official title: Optimizing Antibiotic Use in Neonatal Intensive Care Units: A Collaborative Antimicrobial Stewardship Program in China

Status Recruiting

Clinical Trial Summary

This project aims to reduce antibiotic use in Chinese neonatal intensive care units (NICU) by 1) developing an adaptable framework of NICU-targeted antimicrobial stewardship programs (ASP); 2) implementing the NICU-targeted ASP in NICUs using a collaborative quality improvement method; and 3) evaluating the impact of ASP implementation on neonatal antibiotic use.

Clinical Trial Description

Antibiotics overuse has been a critical problem in Chinese NICUs associated with the emerging antimicrobial resistance crisis. NICU-targeted ASP have rarely been implemented in Chinese NICUs. Collaborative quality improvement methods have been shown to facilitate clinical practice changes and improve outcomes.

In this two-year interventional pre-and post-study, a NICU-targeted ASP will be developed and implemented in Chinese NICUs using the collaborative quality improvement method. The investigators hypothesize that implementing the targeted ASP using a collaborative quality improvement method will reduce the overall antibiotic days of therapy by 20% over a two-year period, comparing the last year of intervention and the last year of baseline period before ASP implementation. ;

Related Conditions & MeSH terms

• Neonates

• NCT number: NCT05073549
• Study type: Interventional
• Source: Children's Hospital of Fudan University
• Contact: Siyuan Jiang, PhD
• Phone: 8613761644971
• Email: jiangsiyuan@fudan.edu.cn
• Status: Recruiting
• Phase: N/A
• Start date: October 1, 2021
• Completion date: December 31, 2023