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Effect of Recombinant Human Granulocyte Colony- Stimulating Factor on CD11b in Septic Neonates

Neonatal Sepsis Clinical Trial

Official title:
In Vivo Effect of Recombinant Human Granulocyte Colony- Stimulating Factor on Neutrophilic Expression of CD11b in Septic Neonates

Clinical Trial Summary

The investigators aimed to evaluate the effect of G-CSF administration in septic neonates on neutrophil production and CD11b expression.

Clinical Trial Description

Neonates are susceptible to septicemia secondary to quantitative and qualitative neutrophilic defects. Granulocyte-colony stimulating factor (G-CSF) stimulates myeloid progenitor cell proliferation and induces selective neutrophil functions. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01479114
Study type Interventional
Source Ain Shams University
Contact
Status Completed
Phase Phase 4
Start date April 2009
Completion date May 2010
View Details
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