Clinical Trials Logo
  1. Home
  2. Neonatal Respiratory Distress
  3. NCT04051762

A Comparative Study Between Postextubation of Preterm Infants Into High-Flow Nasal Cannulae V.S Nasal Continuous Positive Airway Pressure

Neonatal Respiratory Distress Clinical Trial

Official title:
A Comparative Study Between Postextubation of Preterm Infants Into High-Flow Nasal Cannulae V.S Nasal Continuous Positive Airway Pressure

Clinical Trial Summary

The investigators hypothesize that there is a growing trend of the feasibility of HFNC as an alternative to other forms of non-invasive ventilation mechanism to provide continuous distending pressure to preterm infants. However, there remains uncertainty about the efficacy and safety of HFNC in this population.

Clinical Trial Description

Our primary outcome is to determine whether postextubation respiratory support via heated humidified high-flow nasal cannula results in a greater proportion of infants younger than 34 weeks gestation being successfully extubated after a period of endotracheal positive pressure ventilation compared with conventional (NCPAP).

The following study will be conducted in the neonatal intensive care unit (NICU) of Gynecology and Obstetric department of Kasr El Aini hospital and neonatal intensive care unit of Military Hospital throughout a time interval of at least 6 months for a minimum of 100 preterm infants.

Infants will be eligible for the study if they born at less than 34 weeks' gestation, required endotracheal intubation and positive pressure ventilation, and considered ready for extubation by the clinical team.

The investigators will assign extubation of preterm ventilated infants (50 preterm infant) in NICU of Military Hospital into HHFNC and extubation of preterm ventilated infants (50 preterm infant) in (NICU) of Gynecology and Obstetric department of Kasr El Aini hospital into NCPAP (50 preterm infant). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04051762
Study type Observational
Source Cairo University
Contact
Status Completed
Phase
Start date June 1, 2017
Completion date July 30, 2018
View Details
See also
  Status Clinical Trial Phase
Terminated NCT05030012 - Maintaining Optimal HVNI Delivery Using Automatic Titration of Oxygen in Preterm Infants N/A
Active, not recruiting NCT04780412 - Efficacy of Misoprostol in Prevention of Neonatal Respiratory Morbidity in Parturient at Early Term Elective Caesarian Section Phase 3
Completed NCT05257499 - In-person Versus Online Debriefing in HBB N/A
Terminated NCT04096235 - A Study to Evaluate the Use of the Neotech RAM Nasal Cannula for CPAP and Bi-PAP Application in Infants 28-42 Weeks Gestation in a Neonatal Intensive Care Unit (NICU) N/A
Recruiting NCT05737095 - Study of the Feasibility of Early Lung Ultrasound in Neonatal Respiratory Distress in Premature Newborns Born Between 32 Weeks of Amenorrhea and 36 Weeks Plus 6 Days of Amenorrhea, Hospitalized in the Neonatal Pediatrics and Intensive Care Units of the Dijon University Hospital
Completed NCT06171867 - PNEUMACRIT Device for Neonatal Cardio Respiratory Monitoring N/A
Recruiting NCT02030691 - Tolerance of nHFPV Versus nCPAP in Neonatal Respiratory Distress N/A
Not yet recruiting NCT06372951 - Lung Ultrasound in Neonatal Intensive Care Units
Not yet recruiting NCT06292338 - Lung Sonar in Neonatal Respiratory Disorders
Not yet recruiting NCT05144724 - Volume Targeted Mask Ventilation Versus Pressure Ventilation in Preterm Infants N/A
Completed NCT06198478 - Tandem: Skin-to-skin Transfer From the Delivery Room to the Neonatal Unit
Recruiting NCT06356909 - Study of PREMEdication Before Laryngoscopy in Neonates in France
Recruiting NCT03239327 - Vaginal Misoprostol to Improve the Neonatal Respiratory Outcome N/A
Not yet recruiting NCT03899597 - The Role of ARTificial Uterine CONtractions in Perinatal Respiratory Morbidity of Term Infants Delivered by Elective Caesarean Section N/A
Recruiting NCT02978976 - Effect of Antenatal Steroid on Pulmonary Artery Blood Flow Phase 4
Completed NCT06285669 - Effects of Kinesiotaping on Respiratory Muscles in Very Preterm Infants N/A
Recruiting NCT06207994 - PRICO: OPTI Target Range N/A
Recruiting NCT05274386 - Evaluation of the Impact of SpO2 Averaging Time on Performance of an Automatic FiO2 Control System: a Randomized Study N/A
Recruiting NCT02020993 - Urine NT-ProBNP in Neonatal Respiratory Distress N/A
Recruiting NCT04947215 - The Association Between LPCAT1 Genetic Polymorphism and Stress Biomarkers in Neonatal Respiratory Distress Syndrome