Neonatal Mortality Clinical Trial
Official title:
Newborn Antiseptic Washing and Neonatal Mortality-Nepal
Neonatal mortality and morbidity is common in Nepal and the vast majority of women deliver
babies at home without a skilled birth attendant.
The purpose of this project is two-fold: 1) to evaluate whether washing a newborn child with
a dilute antiseptic solution soon after birth can reduce mortality in the first 4 weeks of
life and 2) to evaluate whether cleaning the umbilical cord and stump with either soap and
water or an antiseptic solution for the first few days of life can reduce umbilical cord
infections.
Status | Completed |
Enrollment | 17000 |
Est. completion date | January 2006 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A to 10 Days |
Eligibility |
Inclusion Criteria: - All liveborn infants born in the study area Exclusion Criteria: - Newborn infants who died prior to study staff arriving to conduct the interventions |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Nepal | Nepal Nutrition Intervention Project-Sarlahi | Kathmandu and Sarlahi District | |
United States | Johns Hopkins Bloomberg School of Public Health | Baltimore | Maryland |
Lead Sponsor | Collaborator |
---|---|
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Bill and Melinda Gates Foundation, United States Agency for International Development (USAID) |
United States, Nepal,
Falle TY, Mullany LC, Thatte N, Khatry SK, LeClerq SC, Darmstadt GL, Katz J, Tielsch JM. Potential role of traditional birth attendants in neonatal healthcare in rural southern Nepal. J Health Popul Nutr. 2009 Feb;27(1):53-61. — View Citation
Karas DJ, Mullany LC, Katz J, Khatry SK, LeClerq SC, Darmstadt GL, Tielsch JM. Home care practices for newborns in rural southern Nepal during the first 2 weeks of life. J Trop Pediatr. 2012 Jun;58(3):200-7. doi: 10.1093/tropej/fmr057. Epub 2011 Jun 24. — View Citation
Lee AC, Mullany LC, Tielsch JM, Katz J, Khatry SK, Leclerq SC, Adhikari RK, Darmstadt GL. Community-based stillbirth rates and risk factors in rural Sarlahi, Nepal. Int J Gynaecol Obstet. 2011 Jun;113(3):199-204. doi: 10.1016/j.ijgo.2010.12.015. Epub 2011 — View Citation
Lee AC, Mullany LC, Tielsch JM, Katz J, Khatry SK, LeClerq SC, Adhikari RK, Darmstadt GL. Incidence of and risk factors for neonatal respiratory depression and encephalopathy in rural Sarlahi, Nepal. Pediatrics. 2011 Oct;128(4):e915-24. doi: 10.1542/peds. — View Citation
Lee AC, Mullany LC, Tielsch JM, Katz J, Khatry SK, LeClerq SC, Adhikari RK, Shrestha SR, Darmstadt GL. Risk factors for neonatal mortality due to birth asphyxia in southern Nepal: a prospective, community-based cohort study. Pediatrics. 2008 May;121(5):e1 — View Citation
Lee AC, Mullany LC, Tielsch JM, Katz J, Khatry SK, LeClerq SC, Adhikari RK, Shrestha SR, Darmstadt GL. Verbal autopsy methods to ascertain birth asphyxia deaths in a community-based setting in southern Nepal. Pediatrics. 2008 May;121(5):e1372-80. doi: 10. — View Citation
Mullany LC, Darmstadt GL, Coffey P, Khatry SK, LeClerq SC, Tielsch JM. A low cost, colour coded, hand held spring scale accurately categorises birth weight in low resource settings. Arch Dis Child. 2006 May;91(5):410-3. Epub 2006 Feb 7. — View Citation
Mullany LC, Darmstadt GL, Katz J, Khatry SK, LeClerq SC, Adhikari RK, Tielsch JM. Development of clinical sign based algorithms for community based assessment of omphalitis. Arch Dis Child Fetal Neonatal Ed. 2006 Mar;91(2):F99-104. Epub 2005 Oct 13. — View Citation
Mullany LC, Darmstadt GL, Katz J, Khatry SK, LeClerq SC, Adhikari RK, Tielsch JM. Risk factors for umbilical cord infection among newborns of southern Nepal. Am J Epidemiol. 2007 Jan 15;165(2):203-11. Epub 2006 Oct 25. — View Citation
Mullany LC, Darmstadt GL, Katz J, Khatry SK, Leclerq SC, Adhikari RK, Tielsch JM. Risk of mortality subsequent to umbilical cord infection among newborns of southern Nepal: cord infection and mortality. Pediatr Infect Dis J. 2009 Jan;28(1):17-20. doi: 10. — View Citation
Mullany LC, Darmstadt GL, Katz J, Khatry SK, Tielsch JM. Effect of instrument precision on estimation of low birth weight prevalence. J Perinatol. 2005 Jan;25(1):11-3. — View Citation
Mullany LC, Darmstadt GL, Khatry SK, Katz J, LeClerq SC, Shrestha S, Adhikari R, Tielsch JM. Topical applications of chlorhexidine to the umbilical cord for prevention of omphalitis and neonatal mortality in southern Nepal: a community-based, cluster-rand — View Citation
Mullany LC, Darmstadt GL, Khatry SK, LeClerq SC, Katz J, Tielsch JM. Impact of umbilical cord cleansing with 4.0% chlorhexidine on time to cord separation among newborns in southern Nepal: a cluster-randomized, community-based trial. Pediatrics. 2006 Nov; — View Citation
Mullany LC, Darmstadt GL, Khatry SK, Leclerq SC, Tielsch JM. Relationship between the surrogate anthropometric measures, foot length and chest circumference and birth weight among newborns of Sarlahi, Nepal. Eur J Clin Nutr. 2007 Jan;61(1):40-6. Epub 2006 — View Citation
Mullany LC, Darmstadt GL, Khatry SK, LeClerq SC, Tielsch JM. Safety of neonatal skin cleansing in rural Nepal. Indian Pediatr. 2006 Feb;43(2):117-24. — View Citation
Mullany LC, Darmstadt GL, Khatry SK, Tielsch JM. Traditional massage of newborns in Nepal: implications for trials of improved practice. J Trop Pediatr. 2005 Apr;51(2):82-6. Epub 2005 Jan 26. — View Citation
Mullany LC, Darmstadt GL, Tielsch JM. Role of antimicrobial applications to the umbilical cord in neonates to prevent bacterial colonization and infection: a review of the evidence. Pediatr Infect Dis J. 2003 Nov;22(11):996-1002. Review. — View Citation
Mullany LC, Darmstadt GL, Tielsch JM. Safety and impact of chlorhexidine antisepsis interventions for improving neonatal health in developing countries. Pediatr Infect Dis J. 2006 Aug;25(8):665-75. Review. — View Citation
Mullany LC, Katz J, Khatry SK, Leclerq SC, Darmstadt GL, Tielsch JM. Incidence and seasonality of hypothermia among newborns in southern Nepal. Arch Pediatr Adolesc Med. 2010 Jan;164(1):71-7. doi: 10.1001/archpediatrics.2009.239. — View Citation
Mullany LC, Katz J, Khatry SK, LeClerq SC, Darmstadt GL, Tielsch JM. Neonatal hypothermia and associated risk factors among newborns of southern Nepal. BMC Med. 2010 Jul 8;8:43. doi: 10.1186/1741-7015-8-43. — View Citation
Mullany LC, Katz J, Khatry SK, LeClerq SC, Darmstadt GL, Tielsch JM. Risk of mortality associated with neonatal hypothermia in southern Nepal. Arch Pediatr Adolesc Med. 2010 Jul;164(7):650-6. doi: 10.1001/archpediatrics.2010.103. — View Citation
Mullany LC, Katz J, Li YM, Khatry SK, LeClerq SC, Darmstadt GL, Tielsch JM. Breast-feeding patterns, time to initiation, and mortality risk among newborns in southern Nepal. J Nutr. 2008 Mar;138(3):599-603. — View Citation
Mullany LC, Khatry SK, Sherchand JB, LeClerq SC, Darmstadt GL, Katz J, Gauchan P, Adhikari RK, Rana A, Tielsch JM. A randomized controlled trial of the impact of chlorhexidine skin cleansing on bacterial colonization of hospital-born infants in Nepal. Pediatr Infect Dis J. 2008 Jun;27(6):505-11. doi: 10.1097/INF.0b013e31816791a2. — View Citation
Rhee V, Mullany LC, Khatry SK, Katz J, LeClerq SC, Darmstadt GL, Tielsch JM. Maternal and birth attendant hand washing and neonatal mortality in southern Nepal. Arch Pediatr Adolesc Med. 2008 Jul;162(7):603-8. doi: 10.1001/archpedi.162.7.603. — View Citation
Rosenberg RE, Ahmed S, Saha SK, Ahmed AS, Chowdhury MA, Law PA, Choi Y, Mullany LC, Tielsch JM, Katz J, Black RE, Santosham M, Darmstadt GL. Simplified age-weight mortality risk classification for very low birth weight infants in low-resource settings. J — View Citation
Sharma V, Katz J, Mullany LC, Khatry SK, LeClerq SC, Shrestha SR, Darmstadt GL, Tielsch JM. Young maternal age and the risk of neonatal mortality in rural Nepal. Arch Pediatr Adolesc Med. 2008 Sep;162(9):828-35. doi: 10.1001/archpedi.162.9.828. — View Citation
Thatte N, Mullany LC, Khatry SK, Katz J, Tielsch JM, Darmstadt GL. Traditional birth attendants in rural Nepal: knowledge, attitudes and practices about maternal and newborn health. Glob Public Health. 2009;4(6):600-17. doi: 10.1080/17441690802472406. — View Citation
Tielsch JM, Darmstadt GL, Mullany LC, Khatry SK, Katz J, LeClerq SC, Shrestha S, Adhikari R. Impact of newborn skin-cleansing with chlorhexidine on neonatal mortality in southern Nepal: a community-based, cluster-randomized trial. Pediatrics. 2007 Feb;119 — View Citation
* Note: There are 28 references in all — Click here to view all references
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Primary | neonatal mortality | |||
Primary | umbilical cord infection |
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