Exploring Vancomycin Disposition in Neonates

Status Recruiting

Clinical Trial Summary

Vancomycin is already used for decades in neonates. However, there are remaining questions concerning vancomycin disposition in this population. The purpose of this study is first of all to perform a paired analysis of serum vancomycin concentrations using an immunoassay versus a reference liquid chromatography-tandem mass spectrometry method. Secondly, we aim to determine vancomycin protein binding and its covariates in neonates.

Clinical Trial Description

Exploration of vancomycin disposition in neonates:

Objective 1: Paired analysis of (total) serum vancomycin concentrations in neonates using the currently available immunoassay (Cobas c702) versus a reference liquid chromatography-tandem mass spectrometry method (LC-MS/MS).

Objective 2: The determination of vancomycin protein binding and its covariates in neonates. ;

Study Design

Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Neonatal Infection

Clinical Trial Details

NCT number	NCT02096536
Study type	Interventional
Source	Universitaire Ziekenhuizen Leuven
Contact	Anne Smits, MD
Phone	003216341564
Email	anne.smits@uzleuven.be
Status	Recruiting
Phase	Phase 4
Start date	April 2014
Completion date	January 2016

View Details

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