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Analysis of Differential Proteins and Maternal Influencing Factors of Septic Shock in Neonates

Neonatal Disease Clinical Trial

Official title:
Analysis of Differential Proteins and Maternal Influencing Factors of Septic Shock in Neonates Born to ≤32-week Preterm Infants or Infected Mothers During Pregnancy

Clinical Trial Summary

1. Explore 32 weeks of premature infants or maternal pregnancy infection of newborn septic shock maternal influence factors. 2. Through maternal blood samples before delivery and labor cord blood sample screening and septic shock related proteomics analysis, explore the relationship between the difference protein and septic shock and prognosis, and explore the pathway mechanism, in order to prevent and reduce the occurrence of septic shock in premature infants

Clinical Trial Description

The birth cohort was established with 32 weeks of premature infants or maternal infection during pregnancy.Whole proteomic analysis was performed on maternal blood before delivery and umbilical cord blood samples at delivery,and screscreen differential proteins associated with septic shock and classify these proteins as leak factor into exposed and non-exposed groups for cohort study.The incidence and mortality of shock,severe brain injury and BPD in the two groups were compared, and the mechanism of the differential protein was studied to provide early warning in children with septic shock. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06206590
Study type Observational
Source Guangdong Women and Children Hospital
Contact dongju ma
Phone +86 188 9853 7230
Email 864970051@qq.com
Status Recruiting
Phase
Start date November 1, 2023
Completion date December 31, 2025
View Details
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