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Clinical Trial Summary

The prognosis of pancreatic cancer is extremely poor. Current guidelines recommend Nab-paclitaxel, Gemcitabine and modified Folfirinox as the first-line chemotherapeutic regimen. Studies have shown that sequential chemotherapeutic regimen can effectively delay the drug resistance and improve the effect of chemotherapy. Here investigators intend to assess the effect of sequential treatment with Nab-paclitaxel plus Gemcitabine and modified Folfirinox as neoadjuvant chemotherapy for resectable pancreatic adenocarcinoma.


Clinical Trial Description

Investigators chose resectable pancreatic adenocarcinoma patients. The planned treatment was given to the participants after randomization. Tumor size, recurrence-free survival, overall survival, drugs related side effects and other endpoints events were recorded and analyzed, to assess the sequential treatment with Nab-paclitaxel plus Gemcitabine and modified Folfirinox could or couldn't benefit the prognosis of resectable pancreatic adenocarcinoma. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03750669
Study type Interventional
Source Second Affiliated Hospital, School of Medicine, Zhejiang University
Contact Tingbo Liang, MD PhD
Phone 8613666676128
Email liangtingbo@zju.edu.cn
Status Recruiting
Phase Phase 3
Start date October 20, 2018
Completion date October 20, 2026

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