Chlamydia Trachomatis Infection Clinical Trial
Official title:
Comparison of Efficacy of Two Combination Regimens for the Treatment of Uncomplicated Neisseria Gonorrhoeae and Chlamydia Trachomatis Coinfection
The frequency of Chlamydia trachomatis and Neisseria gonorrhoeae coinfection can vary depending on their individual incidence and prevalence rates.Single-agent therapy with ceftriaxone is the preferred regimen for treatment of gonococcal infections. If an injectable cephalosporin is not available, cefixime is the only oral cephalosporin that can be used for gonococcal therapy. Doxycycline was recommended for presumptive treatment of chlamydia in nonpregnant individuals with gonococcal infection. The study is conducted to evaluate the effectiveness of two regimens in combination with doxycycline with cefixime or ceftriaxone.
Gonococcal infections, including urethritis, cervicitis, epididymitis, and proctitis, are a significant cause of morbidity among sexually active men and women. The treatment of these sexually transmitted infections (STIs) has evolved over the years, mainly due to the emergence of antibiotic resistance. The frequency of Chlamydia trachomatis and Neisseria gonorrhoeae coinfection can vary depending on their individual incidence and prevalence rates. Ceftriaxone is highly effective against susceptible N. gonorrhoeae. Single-agent therapy with ceftriaxone is the preferred regimen for treatment of gonococcal infections. These doses of ceftriaxone are higher than previously recommended due to concerns regarding rising gonococcal minimum inhibitory concentrations (MICs) worldwide. If an injectable cephalosporin is not available, cefixime is the only oral cephalosporin that can be used for gonococcal therapy. Doxycycline (100 mg orally twice daily for seven days) was recommended for presumptive treatment of chlamydia in nonpregnant individuals with gonococcal infection. The study is conducted to evaluate the effectiveness of two regimens in combination with doxycycline with cefixime or ceftriaxone. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04269434 -
GonoScreen: Efficacy of Screening STIs in MSM
|
N/A | |
Active, not recruiting |
NCT04139629 -
Cohort Study Investigating the Association Between Antichlamydial Antibody Positivity and ART Outcomes in Women With TFI
|
N/A | |
Completed |
NCT03107377 -
Phase 2B/3 Double-blinded Placebo-controlled
|
Phase 2/Phase 3 | |
Completed |
NCT03098329 -
Check it: A New Approach to Controlling Chlamydia Transmission in Young People
|
N/A | |
Recruiting |
NCT03862495 -
Genital CT Treatment to Pregnant Women to Prevent Adverse Pregnancy Outcomes: A Pilot RCT
|
N/A | |
Completed |
NCT05307991 -
Integrating Enhanced HIV PrEP Into a STI Clinic in Lilongwe
|
||
Terminated |
NCT02083276 -
Mecillinam for Treatment of Genital Chlamydia Infection
|
Phase 2 | |
Active, not recruiting |
NCT06131749 -
Genital Tract Infections, the Vaginal Microbiome and Gestational Age at Birth Among Pregnant Women in South Africa
|
||
Completed |
NCT03568695 -
Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae and Mycoplasma Genitalium by Real-time Multiplex Polymerase Chain Reaction (PCR) After Pooling Pharyngeal, Anorectal and Urinary Samples
|
N/A | |
Completed |
NCT01448876 -
Incubation Time and Test of Cure of Chlamydia Trachomatis
|
N/A | |
Not yet recruiting |
NCT06369220 -
A Study of the Cobas® Liat CT/NG/MG Test Versus Current Standard Practice for Managing Participants at Increased Risk of Sexually Transmitted Infections
|
N/A | |
Not yet recruiting |
NCT06395675 -
Clinical Evaluation of the ID NOW™ CT/NG Test
|
N/A | |
Completed |
NCT03970850 -
NeuMoDx PrEDiCTiNG Study Evaluation Plan
|
N/A | |
Completed |
NCT01631201 -
Safety and Efficacy Study of Rifalazil for the Treatment of Chlamydia Trachomatis Infection in Women
|
Phase 2 | |
Recruiting |
NCT05581160 -
Assess the Performance of Metagenomic Sequencing in the Diagnosis of STI (NGS-IST)
|
N/A | |
Not yet recruiting |
NCT03532464 -
Azithromycin Compared With Doxycycline for Treating Anorectal Chlamydia Trachomatis Infection Concomitant to a Vaginal Infection
|
Phase 4 | |
Not yet recruiting |
NCT06234943 -
Pharmacy-based Testing and Treatment for Gonorrhea and Chlamydia
|
N/A | |
Active, not recruiting |
NCT04050540 -
Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP
|
Phase 4 | |
Completed |
NCT04955717 -
Antenatal Chlamydia Trachomatis and Neisseria Gonorrhoeae Testing to Prevent Adverse Neonatal Consequences
|
N/A | |
Active, not recruiting |
NCT05666778 -
Single Arm Trial of Menstrual Cups Among Economically Vulnerable Women to Reduce Bacterial Vaginosis and STIs
|
Phase 2 |