Necrotizing Scleritis Clinical Trial
Official title:
Autologous Perichondrium Transplantation for Replacement of Stem Cells and Their Niche in the Treatment of Necrotizing Scleritis
Necrotizing scleritis with severe ischemia is refractory to conventional treatment because
of avascular necrosis.
The investigators assessed the therapeutic efficacy and safety of autologous perichondrium
transplantation in patients with severe ischemic necrotizing scleritis, and analyzed the
therapeutic effects.
Ischemic necrotizing scleritis patients who showed persistent and progressive scleral
melting were included in this study.
Perichondrium tissue was harvested from the patient's ear cartilage and transplanted to
reconstruct the scleral defect after the necrotic tissue removal.
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment