Necrotizing Fasciitis Clinical Trial
Official title:
Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features
This is a retrospective descriptive study on the clinical and microbiological features of Klebsiella Pneumoniae Necrotizing Fasciitis.
Background. Necrotizing fasciitis is a rapidly progressive, life-threatening infectious
disease that primarily involves soft tissue. Traditionally, group A streptococcus is the
major cause of this disease. In recent years, however, there are increasing case reports of
necrotizing fasciitis solely caused by Klebsiella pneumoniae. There are limited data
regarding clinical and microbiological features of K. pneumoniae strains causing this
disease.
Methods. We plan to review the medical records of necrotizing fasciitis cases treated during
1997-2010 at National Taiwan University Hospital, and compare the clinical features of cases
caused by K. pneumonia and cases caused by group A streptococcus. We also plan to
retrospectively identify necrotizing fasciitis-associated K. pneumoniae strains stored at
-80oC at National Taiwan University Hospital, and perform virulence-associated
hypermucoviscosity phenotyping, wzy (magA locus) and rmpA genotyping, and detection of 20-kb
kfu/PTS genomic region and other iron-uptake systems.
Expected Results. This study is expected to yield the following important information: (1)
The prevalence of monomicrobial K. pneumoniae necrotizing fasciitis cases among all
necrotizing fasciitis cases at our hospital during the study period; (2) The distinct
clinical features of K. pneumoniae necrotizing fasciitis, using group A streptococcal
necrotizing fasciitis as the comparison group; (3) The microbiologic characteristics of K.
pneumoniae strains causing monomicrobial necrotizing fasciitis, including hypermucoviscosity
phenotype, wzy (magA locus) and rmpA genotype, and the presence of iron-uptake systems.
;
Time Perspective: Retrospective
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