Necrotising Enterocolitis Clinical Trial
Official title:
The Use of Different Imaging Modalities in Diagnosing Necrotizing Enterocolitis in Preterm Infants.
Background Necrotizing enterocolitis (NEC) is one of the most serious conditions in newborns,
affecting up to 10% of very low birth weight infants (VLBW). In the most premature population
mortality rates can rise as high as 60%.
Typical findings on abdominal radiography (AR) include pnuematosis intestinalis (PI), portal
vein gas (PVG) and pneumoperitoneum, but are sometimes not present even in severe cases.
Abdominal ultrasound (AUS) can depict PI, PVG and pnuemoperitoneum (in some cases a head of
AR), but it also provides other crucial information such as bowel wall viability (thickness
or thinning) and free abdominal fluid. These additional findings are helpful in expediting
diagnosis and management of NEC.
Methods and analysis The hypothesis being tested is that preforming an AUR in patients with
clinical symptoms of NEC but inconclusive/normal AR will enhance detection rates, and
expedite treatment in infants born at <32 weeks.
Discussion The use of AUS together with AR as an add-on test may increase the accuracy of
diagnosing NEC, and precipitate treatment. Swift implementation of antibiotics and bowel rest
is extremely important. To our best knowledge, our study will be the first to focus only on
VLBW, who are most prone to NEC. It will also be the first multi-centre study evaluating the
use of AUS as an add-on test, enabling us to recruit a significantly higher number of
patients compared to published studies.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05530330 -
Markers of Platelet Activation foR Identification of Late Onset Sepsis in Preterm Infants
|
||
| Completed |
NCT04277533 -
Predictors of Neonatal Necrotizing Enterocolitis
|
||
| Completed |
NCT01899677 -
The Efficacy of Symbiotic on Cytokines
|
Phase 3 | |
| Recruiting |
NCT02132819 -
Withholding Feeds During Red Blood Cell Transfusion and TRAGI
|
Phase 4 | |
| Completed |
NCT04792918 -
Characterization of Intestinal Microbiota Stability in Preterm Born Neonates
|
||
| Completed |
NCT01287507 -
Lactoferrin Prophylaxis in VLBW and Regulator T-cells
|
N/A | |
| Not yet recruiting |
NCT06092463 -
The Intestinal Innate Immune System in Newborns. Development and Inflammation in Health and Disease
|
||
| Not yet recruiting |
NCT05117164 -
Enteral Feeding in Infants With Duct Dependant Lesions.
|
N/A |