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Safety and Efficacy of Oral Cannabis in Chronic Spine Pain

Neck Pain Clinical Trial

Official title:
Safety and Efficacy of Oral Cannabis in Chronic Spine Pain

Clinical Trial Summary

The overall objectives of this study are to investigate the efficacy of extended cannabis treatment to reduce patient exposure to prescription opioids through its use 1) as a non-opioid analgesic treatment, and 2) as a therapy for reducing high-dose opioid use in patients with chronic spine pain.

Clinical Trial Description

This randomized, placebo-controlled clinical trial is designed to elucidate the role of extended oral cannabis treatment in the alleviation of chronic spine pain and reduction of high-dose opioid use. This trial includes two study arms: Analgesia Arm and Reduction Arm. The Analgesia Arm uses a within-subject crossover design to determine whether daily treatment with an oral cannabis solution for 6 weeks significantly reduces spine pain compared to placebo. The Reduction Arm uses a parallel design to determine whether daily treatment with an oral cannabis solution for 13 weeks results in a greater reduction of pain and opioid intake than placebo treatment. It will also assess the impact of extended cannabis treatment on opioid craving and symptoms of opioid withdrawal in participants tapering their high-dose opioids. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05052541
Study type Interventional
Source University of Colorado, Denver
Contact Alan Morris, PhD
Phone 303-724-0923
Email CUPainStudies@cuanschutz.edu
Status Not yet recruiting
Phase Phase 3
Start date February 2023
Completion date June 2024
View Details
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