Pain Modulatory Profiles in Massage for Individuals With Neck Pain

Status Completed

Clinical Trial Summary

One in ten adults experience widespread pain. Neck pain, for example, is a prevalent condition with a high rate of recurrence that affects between 10.4% and 21.3% of the population annually. Massage is a common manual therapy intervention for individuals with musculoskeletal pain. However, the mechanisms of massage are not well established. Also, the conditioned pain modulation (CPM) paradigm is a dynamic quantitative sensory testing measure of a pain inhibitory process in which pain sensitivity is lessened in response to a remotely applied painful stimulus. This study will evaluate the association between pain inducing massage and the conditioned pain modulation paradigm in participants with a history of neck pain.

Clinical Trial Description

Conditioned pain modulation (CPM) is the physical manifestation of the diffuse noxious inhibitory control (DNIC), an endogenous pain inhibitory pathway in which pain inhibits pain. Conditioned pain modulation is less efficient in individuals with chronic pain conditions and it is a predictor for the development of chronic pain. Massage is a common manual therapy intervention for individuals with musculoskeletal pain. Greater changes in pain sensitivity occur following pain inducing massage suggesting a mechanism dependent upon the efficiency of the conditioned pain modulation response. Previous research has indicated pain inducing massage is more effective than pain free massage suggesting a mechanism dependent upon conditioned pain modulation. The study team will evaluate the association between pain inducing massage and the conditioned pain modulation paradigm. Participants with neck pain will be randomly assigned to receive a pain inducing massage, pain free massage, or a coldpressor task. Pre-and post intervention pain will be assessed. The study team will determine if analgesia induced by pain inducing massage is similar to the conditioned pain modulation paradigm and if baseline conditioned pain modulation predicts responders to pain inducing massage and short term clinical outcomes in patients with a history of neck pain. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03534739
Study type	Interventional
Source	University of Florida
Contact
Status	Completed
Phase	N/A
Start date	June 20, 2018
Completion date	June 9, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05293847` - Postural Based Telerehabilitation in Mechanic Neck Pain	N/A
Completed	`NCT04060004` - The Effects of Dry Needling on the Superficial Neck Musculature	N/A
Recruiting	`NCT06204627` - TDCS* and Laterality Trainnning in Patients With Chronic Neck Pain	N/A
Active, not recruiting	`NCT05870371` - The Effect of the Feldenkrais Method on Pain and Function in Patients With Chronic Neck Pain	N/A
Completed	`NCT06049316` - Scapular Stabilization vs Functional Exercises on Chronic Neck Pain	N/A
Recruiting	`NCT05944354` - Wearable Spine Health System for Military Readiness
Completed	`NCT02731014` - Dry Needling for Patients With Neck Pain	N/A
Completed	`NCT02904668` - Self-management Program in Chronic Neck Pain	N/A
Completed	`NCT03147508` - Investigating Clinical Indicators of Spine Related Dysfunction Patterns. A Clinical Study on Neck Pain Patients.
Completed	`NCT02882061` - Examination of Cervical Thoracic Differentiation Testing in Individuals With Neck Pain	N/A
Completed	`NCT02638987` - EMG Activity Before, During and After Dry Needling	N/A
Active, not recruiting	`NCT02843269` - Multiple-component Workplace FRamed Intervention to Decrease Occupational Muscle Pain - FRIDOM	N/A
Enrolling by invitation	`NCT02485795` - Observational Study of the Impact of Genetic Testing on Healthcare Decisions and Care in Interventional Pain Management	N/A
Completed	`NCT02245425` - Comparison of Two Thoracic Manipulation Techniques to Improve Neck Pain	N/A
Completed	`NCT02235207` - Effectiveness of Fustra—Exercise Program in Neck and Low Back Pain	N/A
Completed	`NCT02225873` - The Effectiveness of Exercises Protocol in Management of Neck Pain	N/A
Completed	`NCT02190890` - Dry Needling Dosage in the Treatment of Myofascial Neck Pain	N/A
Completed	`NCT02051478` - Thoracic Manipulation and Mobilization for Neck Pain	N/A
Completed	`NCT01938209` - A Comparison of Seated Thoracic Manipulation and Targeted Supine Thoracic Manipulation on Cervical Flexion Motion and Pain	N/A
Completed	`NCT01205542` - Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck (VIMS) - Shoulder Function	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.