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Pregabalin for the Prevention of Chemotherapy Induced Nausea and Vomiting

Nausea Clinical Trial

Official title:
Phase II Study of Pregabalin for the Prevention of Chemotherapy Induced Nausea and Vomiting

Clinical Trial Summary

phase II randomized, double-blind, placebo-controlled trial to investigate whether pregabalin can improve the complete control of nausea and vomiting (primary end point)

Clinical Trial Description

chemotherapy-naive patients, scheduled to receive moderately and highly emetogenic chemotherapy.

All patients will receive IV ondansetron 8 mg, dexamethasone 10 mg and ranitidine 50 mg before chemotherapy on day 1 and oral dexamethasone 4 mg, bd, on days 2 and 3.

Patients will be randomly assigned to take pregabalin 75 mg or placebo, bd, from the night before chemotherapy to day 5. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04181346
Study type Interventional
Source Faculdade de Medicina do ABC
Contact Felipe Cruz, PhD
Phone 5511981388214
Email felipemcruz@yahoo.com.br
Status Recruiting
Phase Phase 2
Start date September 1, 2019
Completion date February 28, 2020
View Details
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