Nausea Clinical Trial
Official title:
Randomized Double Control Study to Assess the Efficacy of Administering 1 ml of Glycopyrrolate With the Spinal Dose in Minimizing Nausea and Vomiting in Patients Undergoing Cesarean Section Under Spinal Anesthesia
In parturients undergoing Cesarean section under spinal anesthesia, co-loading of 1 liter of crystalloids, with placing the spinal, along with administering a phenylephrine infusion and glycopyrrolate, enables placing a spinal with minimal perioperative nausea and vomiting and good intra and post-operative pain relief.
The hypothesis of this study is as follows: In parturients undergoing Cesarean section under
spinal anesthesia, co-loading of 1 liter of crystalloids, with placing the spinal, along with
administering a phenylephrine infusion and glycopyrrolate, enables placing a spinal with
minimal perioperative nausea and vomiting and good intra and post-operative pain relief.
The study group will receive phenylephrine infusion [dilution 100micrograms /cc] Rate of
infusion 50micrograms /hour, approximately 30ml/hour To be started immediately after the
placement of the spinal anesthetic Patient will also be given .4mg [1cc of glycopyrrolate],
with the starting of the infusion
The control group, will receive phenylephrine infusion [dilution 100micrograms /cc] Rate of
infusion 50micrograms /hour, approximately 30ml/hour To be started immediately after the
placement of the spinal anesthetic Patient will also be given a placebo [1cc of N saline],
with the starting of the infusion
Following the administration of the study drug/placebo, the patient will be monitored for
severity of nausea , vomiting and pain at 5 minutes intervals from placement of the spinal to
delivery of the baby, and then at 15 minutes intervals from delivery of the baby till the end
of the surgery ( the cesarean section)
;
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