Nausea Clinical Trial
Official title:
Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo
- Vertigo complaint is one of the common cause of patients who applied to emergency
services.
- Patients who have applied to emergency services with vertigo complaint mostly have
nausea as an additionally symptom to this complaint and anti-emetic agents can be used
in their treatments very often.
- The investigators purpose is to investigate the advantages of Dimenhydrinate and
metoclopramide to each other in the treatment of vertigo and the vertigo accompanied by
nausea
Status | Completed |
Enrollment | 200 |
Est. completion date | May 2013 |
Est. primary completion date | May 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - between 18 to 65 years old patients, - had vertigo and accompanied nausea or vomiting [VAS (visual analog scale) score >5] during their emergency department episode of care for which the attending physician recommended intravenous antiemetic medication. Exclusion Criteria: - abnormal vital signs, - women who were pregnant or lactation, - those with a history of epilepsy, - acute psychiatric symptoms, - organic brain disease, - parkinson's disease or phaeochromocytoma, - or any known allergy to the study drugs, - uncooperative individuals, - use of any antiemetic drug in the previous 8 hours or previous delivery of intravenous fluids during the emergency department episode of care, - currently undergoing chemotherapy or radiotherapy, - mechanical obstruction or perforation, - gastrointestinal bleeding, - inability to understand study explanation or outcome measures (any reason), - known allergy or previous adverse reaction to metoclopramide or dimenhydrinate, - and patients who refused to participate study. |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Pamukkale University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | compare the effects of intravenous dimenhydrinate and metoclopramide in the treatment of nausea due to vertigo in emergency setting. (nausea and vertigo scores as measured by Visual Analogue Scale.) | - participants will be followed for the duration of hospital stay, an expected average of 30 minutes. | Change from Baseline in nausea and vertigo scores at 30 minutes. | No |
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