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Prevention of Unmitigated Chemotherapy-induced Emesis — PUCE  

Chemotherapy-induced Nausea and Vomiting Clinical Trial

Official title:
PUCE Study: Prevention of Unmitigated Chemotherapy-induced Emesis

Clinical Trial Summary

Chemotherapy-induced nausea and vomiting (CINV) remains a major obstacle to patient care and continues to decrease quality of life. Despite the addition of medications and antiemetic regimens, doctors' ability to control CINV is still inadequate: even moderately-emetogenic chemotherapy regimens cause roughly 20% of patients to have vomiting and over 40% to experience significant nausea. In this study, the investigators test a transcranial vibrating system that has shown great promise at reducing nausea and vomiting. .

Clinical Trial Description

Chemotherapy-induced nausea and vomiting (CINV) remains a major obstacle to cancer patient care despite numerous medications being available to prevent and treat CINV. CINV decreases quality of life in roughly one third of patients receiving highly emetogenic chemotherapy. In addition, roughly half to two thirds of all patients receiving chemotherapy require rescue anti-emetic medications despite being given guideline-based prophylactic anti-emetics.The anti-emesis armamentarium continues to grow with new medications, including olanzapine and fosaprepitant, being studied in recent years. However, despite the addition of these medications and guideline-based antiemetic regimens, the ability to control CINV is still inadequate as even moderately-emetogenic chemotherapy regimens cause roughly 20% of patients to have vomiting and over 40% to experience significant nausea. In this study, the investigators aim to test a new transcranial vibrating system that has shown promise in phase I studies for treating dizziness, motion sickness and nausea. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03996863
Study type Interventional
Source Otolith Labs
Contact
Status Withdrawn
Phase N/A
Start date August 1, 2019
Completion date August 1, 2019
View Details
See also
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