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Anlotinib, Penpulimab and Capecitabine in Recurrent/Metastatic Nasopharyngeal Carcinoma — ALTER-HN005  

Nasopharyngeal Neoplasms Clinical Trial

Official title:
The First-line Therapy With the Combination of Anlotinib, Penpulimab and Capecitabine in Recurrent/Metastatic Nasopharyngeal Carcinoma: a Single-arm, Open-label, Phase II Trial

Clinical Trial Summary

First-diagnosed metastasis or recurrence/metastasis NPC Patients will be treated with anlotinib, penpulimab and capecitabine.

Clinical Trial Description

The trial is an open-label, single-arm, phase II clinical trial. This trial plans to enroll patient that is diagnosed with locoregionally advanced nasopharyngeal carcinoma at his/her first diagnosis, and has recurrence/metastasis at least 6 months after completing radiotherapy and chemotherapy for the primary lesion, and has never accepted systemic treatment for recurrent/metastatic lesion before. The first-line treatment is the three-drug treatment plan, including anlotinib, penpulimab and capecitabine, for 4-6 cycles. Then a maintenance treatment will be run, including penpulimab and capecitabine, until PD or intolerance to toxicity. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05807880
Study type Interventional
Source Sun Yat-sen University
Contact Jun Ma, M.D.
Phone +862087343469
Email majun@sysucc.org.cn
Status Not yet recruiting
Phase Phase 2
Start date October 1, 2023
Completion date October 1, 2025
View Details
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