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Nasopharyngeal Neoplasms clinical trials

View clinical trials related to Nasopharyngeal Neoplasms.

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NCT ID: NCT03639467 Recruiting - Clinical trials for Recurrent Nasopharyngeal Carcinoma

Study of Anlotinib Combined With Gemcitabine/Cisplatin in Advanced Nasopharyngeal Carcinoma

Start date: September 18, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

Gemcitabine plus cisplatin (GC) is more effective than fluorouracil plus cisplatin in the treatment of recurrent or metastatic NPC (R/M-NPC). GC is the standard first-line chemotherapy regimen for this population. However, the median progression-free survival was only 7 months for GC regimen. Anlotinib is a kinase inhibitor of receptor tyrosine with multi-targets, especially for VEGFR2、VEGFR3、PDGFRβ and c-Kit, which has strong effect of anti-angiogenesis. This study is aim to evaluate the efficacy and safety of the combination regimen of anlotinib plus GC as first-line treatment for R/M-NPC.

NCT ID: NCT03612219 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

Adjuvant Treatment of Apatinib in Nasopharyngeal Carcinoma

Start date: July 1, 2018
Phase: Phase 2
Study type: Interventional

The study is to evaluate the efficacy and safety of apatinib for adjuvant treatment of High-risk metastasis of nasopharyngeal carcinoma after IMRT with concurrent chemotherapy,including progression-free survival (PFS),evaluation of drug safety.,and overall survival (OS),distant metastasisfree survival (DMFS),locoregional relapse-free survival (LRRFS),and quality of life score (QoL).

NCT ID: NCT03604965 Recruiting - Clinical trials for Locally Advanced Nasopharyngeal Carcinoma

GP Induction Chemotherapy us TPF Adjuvant Chemotherapy Combined With DDP Concurrent Chemoradiotherapy in the Treatment of Locally Advanced NPC

Start date: July 21, 2018
Phase: Phase 3
Study type: Interventional

Through randomized controlled phase III multicenter clinical trials, GP induction chemotherapy vs TPF regimen adjuvant chemotherapy combined with DDP concurrent chemoradiotherapy for the treatment of locally advanced nasopharyngeal carcinoma: the efficacy, toxicity and quality of life, and further improvement Survival rate and improve the quality of life.

NCT ID: NCT03601975 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

Gemcitabine and Cisplatin With/Without Anlotinib in Advanced Nasopharyngeal Carcinoma

Start date: August 27, 2018
Phase: Phase 3
Study type: Interventional

This is a Phase III randomized controlled multi-center trial comparing anlotinib plus Gemcitabine/Cisplatin with placebo plus Gemcitabine/Cisplatin in previous untreated patients with recurrent/metastatic Nasopharyngeal Carcinoma, in order to verify the efficacy and security of anlotinib in mNPC patients.

NCT ID: NCT03588403 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

TOMO Versus IMRT in Nasopharyngeal Carcinoma Patients

Start date: July 1, 2018
Phase:
Study type: Observational

Tomotherapy is a new radiation planning and delivery technology which may allow for delivery of higher radiation doses with less damage to normal tissues. The investigators aim to compare the treatment efficacy and quality of life between tomotherapy and intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma

NCT ID: NCT03578575 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

To Investigate the Molecular Mechanism of Traditional Chinese Medicine Constitution Using Next-generation Sequencing in Nasopharyngeal Carcinoma

Start date: July 26, 2018
Phase: Phase 2
Study type: Interventional

To investigate the molecular mechanism of traditional Chinese medicine constitution, the investigators proposed a randomized, double-blind, placebo-controlled, phase II trial to recruit 120 patients with nasopharyngeal cancer. Next generation sequencing, immune repertoire, gut microbiota, traditional Chinese medicine constitution and tongue diagnosis would be examined before/after 16 weeks of treatment of Danggui Buxue Tang from the beginning of concurrent chemoradiotherapy in this project. The correlation between different examinations would be analyzed to investigate the molecular mechanism of traditional Chinese medicine constitution. Disease survival, recurrence, and quality of life would be also followed up for two years to evaluate the benefit of Danggui BuxueTang.

NCT ID: NCT03574324 Recruiting - Clinical trials for Locally Advanced Nasopharyngeal Carcinoma

TPF Induction Chemotherapy vs PF Adjuvant Chemotherapy Combined With Concurrent Chemoradiotherapy in the Treatment of Locally Advanced NPC

Start date: May 24, 2018
Phase: Phase 3
Study type: Interventional

Through randomized controlled phase III multicenter clinical trials, TPF induction chemotherapy vs. PF regimen adjuvant chemotherapy concurrently Radiotherapy and chemotherapy for the treatment of locally advanced nasopharyngeal carcinoma: the efficacy, toxicity and quality of life, and further improvement Survival rate and improve the quality of life.

NCT ID: NCT03557112 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

By Comparing TPF Induction Chemotherapy Combined With Nimotuzumab Concurrent Radiotherapy and Cisplatin Concurrent Radio-chemotherapy for Locally Advanced NPC

Start date: June 1, 2018
Phase: Phase 2
Study type: Interventional

This study is aimed to investigate the short-term efficacy and toxicities of local advanced nasopharyngeal carcinoma (NPC) treated with TPF regimen induction chemotherapy combined with nimotuzumab concurrent radiotherapy and cisplatin concurrent chemoradiotherapy.

NCT ID: NCT03471403 Recruiting - Clinical trials for Familial Adenomatous Polyposis

Cold Snare Polypectomy for Duodenal Adenomas in Familial Adenomatous Polyposis

COPDA
Start date: October 10, 2017
Phase:
Study type: Observational

The purpose of this study is to collect prospective observational data regarding patients with diagnosed Familial Adenomatous Polyposis (FAP) undergoing cold snare polypectomy for duodenal adenomas

NCT ID: NCT03411954 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

Hippocampus Avoidance During Intensity Modulated Radiotherapy for T4 Nasopharyngeal Carcinoma Patients

Start date: January 1, 2018
Phase: N/A
Study type: Observational

This is a prospective, non-randomized phase III study observing the cognitive function changes with conformal hippocampus avoidance during intensity modulated radiotherapy for T4 nasopharyngeal carcinoma patients.