A Trial of Adjuvant Chemotherapy in Nasopharyngeal Carcinoma Patients With Residual Epstein-Barr Virus (EBV) DNA Following Radiotherapy

Nasopharyngeal Cancer Clinical Trial

Official title:

A Multi-center Prospective Randomized Phase III Trial to Determine the Benefit of Adjuvant Chemotherapy Using Gemcitabine and Cisplatin in Nasopharyngeal Carcinoma Patients With Residual EBV DNA Following Primary Radiotherapy With or Without Concurrent Cisplatin

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00370890
• Other study ID #: HKNPCSG 0502
• Status: Completed
• Phase: Phase 3
• Start date: September 4, 2006
• Est. completion date: October 26, 2021

Study information

• Verified date: February 2022
• Source: Chinese University of Hong Kong
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this trial is to study the benefit of adjuvant chemotherapy using gemcitabine and cisplatin in high risk NPC patients with residual EBV DNA following primary radiotherapy with or without concurrent cisplatin.

Description:

- The standard treatment for nasopharynx cancer is a course of radiotherapy with or without concurrent chemotherapy. This will cure about 80% of patients. For the 20% who developed recurrence or metastases, the prognosis is poor. - Elevated EBV-DNA in plasma at end of radiotherapy has been shown to predict disease recurrence and may be a marker of subclinical residual disease. - This study aims to test whether adjuvant treatment with 6 cycles of a modern chemotherapy regimen (gemcitabine and cisplatin combination) can improve the survival of these high risk patients of nasopharynx cancer who have elevated EBV-DNA after completion of their radiotherapy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 104
• Est. completion date: October 26, 2021
• Est. primary completion date: October 26, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Have given written informed consent, prior to pre-study screening, with the understanding that consent may be withdrawn at any time without prejudice.

2. A histological diagnosis of nasopharyngeal cancer (NPC) must have been established at some time and the investigator must review and confirm the diagnosis prior to randomization.

3. Loco-regional advanced NPC UICC/AJCC Stages IIB, III, IVA or IVB.

4. No evidence of distant metastases in the staging work up at diagnosis.

5. Must have detectable plasma EBV-DNA (> 0 copies/ml) at 6-8 weeks after completion of primary RT or chemo-RT

6. No clinical evidence of persistent loco-regional disease after primary treatment

7. Performance status of ECOG grade 0 or 1.

8. Patients must have adequate organ and marrow function as defined below:

leukocytes >3,000/L; absolute neutrophil count >1,500/L; platelets >100,000/L; total bilirubin <1.5 X institutional upper limit of normal; AST(SGOT)/ALT(SGPT) <2.5 X institutional upper limit of normal; Creatinine clearance > 50 ml/min

9. At least 18 years of age, of either sex.

10. If female, must be either (i) post-menopausal or surgically sterilized, or (ii) use a hormonal contraceptive, intra-uterine device, diaphragm with spermicide for the duration of the study and must be neither pregnant nor breast-feeding.

Exclusion Criteria:

1. Hypercalcaemia: calcium >= 2.7 mmol/L (10.8 mg/dL).

2. Second primary malignancy (except in situ carcinoma of the cervix or adequately treated basal cell carcinoma of the skin).

3. More that 12 weeks after completion of primary radiotherapy.

4. Had received prior adjuvant chemotherapy.

5. Other serious concomitant systemic disorders incompatible with the study (at the discretion of the investigator).

6. Have serious active infection.

7. Patients with peripheral or ototoxicity with a grade of greater than 2.

8. Pregnant or lactating female subjects and subjects with reproductive potential not implementing adequate contraceptive measures.

Related Conditions & MeSH terms

• Nasopharyngeal Cancer
• Nasopharyngeal Carcinoma
• Nasopharyngeal Neoplasms

Intervention

Drug:
• Adjuvant chemotherapy (gemcitabine and cisplatin)
Gemcitabine 1000 mg/m2 in 250 ml NS over 30 mins IV on Day 1 and 8 Cisplatin 40 mg/m2 in 1L NS over 2 h IV on Day 1 and 8 Cycle repeated every 3 weeks for total of 6 cycles

Locations

Country	Name	City	State
Hong Kong	Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital	Hong Kong
Hong Kong	Department of Clinical Oncology, Prince of Wales Hospital	Hong Kong
Hong Kong	Department of Clinical Oncology, Queen Elizabeth Hospital	Hong Kong
Hong Kong	Department of Clinical Oncology, Queen Mary Hospital	Hong Kong
Hong Kong	Department of Clinical Oncology, Tuen Mun Hospital	Hong Kong
Hong Kong	Department of Oncology, Princess Margaret Hospital	Hong Kong

Sponsors (2)

Lead Sponsor	Collaborator
Chinese University of Hong Kong	Hong Kong Nasopharyngeal Cancer Study Group Limited

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Relapse free survival		5 years
Secondary	Overall survival	Overall survival is defined as the duration from the date of randomization to the date of death due to all causes or censored at the date of last follow-up	5 years
Secondary	Loco-regional control		5 years
Secondary	Metastasis-free survival		5 years
Secondary	Toxicity of adjuvant chemotherapy		6 months
Secondary	Correlation of plasma EBV DNA and PET/CT scan with clinical course and outcome		5 years