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Clinical Trial Summary

Oxidative stress at the cellular level and the effects of the antioxidant system on the anesthetic drugs make the anesthesia method more important. Hypotensive anesthesia or controlled hypotension is an anesthetic technique routinely used in many operations (ENT, orthopedic, plastic surgery, etc.) to reduce intraoperative bleeding and to provide a more open surgical area.

In this study, investigators aimed to investigate the effects of hypotensive anesthesia on thiol / disulfide balance from oxidative stress markers.

Hypotensive anesthesia is caused by hypoperfusion and hypoxia-induced oxidative stresses at the tissue level and can initiate cell damage. Many methods can be used alone or in combination to create hypotensive anesthesia. İnvestigators will investigate whether hypotensive anesthesia causes an effect on the cellular level.


Clinical Trial Description

This study will be performed prospectively with 80 participants with ASA 1-2, aged 18-60 years, undergoing hypotensive anesthesia in the operation of the septoplasty in Recep Tayyip Erdoğan University Medical Faculty Training and Research Hospital. Participants with uncontrolled hypertension, diabetes mellitus, cerebrovascular disease, cogulopathy, morbid obesity (BMI ≥35) and renal disease will not be taken. Anesthesia induction and management will be standardized. Hypotension in the participants will be maintained by reducing the mean arterial pressure (MAP) by 30% or 55-65 mmHg according to the initial value. In the study, the heart rate (HR), MAP, peripheral O2 saturation (SpO2), ETCO2 (end-tidal carbon dioxide) values, and BIS (Bispectral index) values showing anesthesia depth are to be followed. Participants will receive venous blood sample of up to 2 ml before the anesthesia induction and 10 minutes to finish of the hypotensive anesthesia, from the untreated vein. Thiol disulfide levels from this blood sample will be studied in the biochemistry research laboratory using the method developed by Erel et al. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03501563
Study type Observational [Patient Registry]
Source Recep Tayyip Erdogan University Training and Research Hospital
Contact Leyla Kazancioglu, Asst. Prof.
Phone +90 464 2123009
Email leylahotaman@hotmail.com
Status Recruiting
Phase
Start date April 5, 2018
Completion date December 30, 2018

See also
  Status Clinical Trial Phase
Recruiting NCT01943929 - Correlation Between Headaches and Septum and Nasal Mucosa Contact N/A
Completed NCT01869673 - A Comparison of the Face Mask and Oral Mask Ventilation After Nasal Surgery Phase 4
Completed NCT02026999 - Sugammadex Versus Neostigmine Use in Patients Undergoing Septoplasty Operations N/A