Treatment of Post-Operative Sinonasal Polyposis With Topical Furosemide

Status Terminated

Clinical Trial Summary

Prior studies have suggested that topical furosemide may reduce the recurrence of sinonasal polyposis following sinus surgery. This project aims to further investigate that claim through a blinded randomized controlled clinical trial following patients who undergo functional sinus surgery for chronic rhinosinusitis with sinonasal polyposis by randomly assigning participants to receive topical furosemide versus placebo nasal spray for 2 months post operatively. Outcomes would be compared at 6 months through endoscopic grading scores using Lund Kennedy and Meltzer scores as well as Sino-Nasal Outcome Test (SNOT-22) scores to measure the rate and degree of recurrence and impact on symptoms in the treatment group versus placebo.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Nasal Polyps

Clinical Trial Details

NCT number	NCT03362515
Study type	Interventional
Source	Thomas Jefferson University
Contact
Status	Terminated
Phase	Phase 2
Start date	December 1, 2017
Completion date	April 14, 2022

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT02071667` - Association of Periostin Levels and Chronic Sinusitis	N/A
Completed	`NCT01623310` - 12-Month OL Intranasal Fluticasone Propionate BID Using OptiNose Device	Phase 3
Completed	`NCT02024659` - Effects and Safety of Budesonide Inhalation Suspension Via Transnasal Nebulization in Nasal Polyps	Phase 2/Phase 3
Completed	`NCT00215787` - Investigation of the Association Between Nasal Polyposis and Extraesophageal Reflux Disease	N/A
Completed	`NCT04996576` - Infrazygomatic Versus Intranasal Injection Sphinopalatine Ganglion Blockade Effect on Surgical Field in FESS	N/A
Recruiting	`NCT03963648` - NO Measurements in Screening for Asthma and OSA, in Patients With CRSwNP	N/A
Recruiting	`NCT05094570` - Interleukin-4Ra Blockade by Dupilumab Decreases Staphylococcus Colonization and Increases Microbial Diversity in CRSwNP	Phase 4
Recruiting	`NCT05009758` - Moving Towards Precision Medicine in United Airways Disease: Unraveling Inflammatory Patterns in Asthmatic Patients With or Without Nasal Polyps	N/A
Completed	`NCT00731185` - Mometasone Furoate Nasal Spray for Treatment of Nasal Polyposis After Surgery (Study P03218)	Phase 3
Active, not recruiting	`NCT03943121` - The Effects of Steroid-eluting Stent Implant for the Treatment of Eosinophilic Chronic Rhinosinusitis With Nasal Polyps	N/A
Active, not recruiting	`NCT03704415` - Aggravated Airway Inflammation: Research on Genomics and Optimal Operative Treatment (AirGOs Operative)	N/A
Not yet recruiting	`NCT06070311` - Wound Healing After Endoscopic Sinus Surgery	N/A
Completed	`NCT02879929` - Development and Validity of the DyNaChron Questionnaire for Chronic Nasal Dysfunction	N/A
Recruiting	`NCT05672030` - Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP
Suspended	`NCT04261582` - Genetics and Genomics of Aspirin Exacerbated Respiratory Disease (AERD)
Recruiting	`NCT05063981` - Treatment With Mepolizumab on Patients With Severe Refractory Eosinophilic Asthma With or Without CRSwNP.
Completed	`NCT05180357` - RANS. Study in Patients With Severe Eosinophilic Asthma and Nasal Polyps.
Completed	`NCT00788463` - A Comparison of Beclomethasone Aqueous Spray and Aerosol Delivery Systems in Nasal Polyps	Phase 2
Completed	`NCT01198912` - Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial	Phase 2
Completed	`NCT03280537` - A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps	Phase 3