Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study

Status Withdrawn

Clinical Trial Summary

This is a study to evaluate the cause of chronic sinus disease. Oral steroids have long been used in the treatment of inflammatory conditions including chronic sinusitis, asthma, and arthritis. However, it is not well known exactly which patients will benefit from steroids when used in the treatment of chronic sinusitis. For some doctors, it is common practice to use these medications prior to planned sinus surgery, to lessen the inflammation and possibly help the healing process. Other doctors feel oral steroids may not be helpful in this way, and there is no conclusive data as to whether this practice has a long term benefit.

Clinical Trial Description

The purpose of this research study is to better understand how this potential treatment option, oral steroids, affects biochemical substances that have been associated with the development of chronic sinusitis and polyps. In order to do this, we need to study people with different forms of chronic sinusitis and compare them to individuals without allergies or sinus disease. We will also look at patients with chronic sinusitis who are treated with oral steroids and compare them to chronic sinus patients who have not received oral steroid therapy prior to surgery. This study may help pave the way to new treatments that address specific parts of the chronic sinus inflammatory pathway.

Hypotheses

1. Oral steroid treatment of patients with CRS will lead to a correction in the inflammation that is observed in sinonasal tissues, nasal brushings, and nasal lavage.

2. Steroid induced changes in inflammation will differ in chronic sinus patients with polyps than in those without polyps.

3. Changes in inflammation will correlate with clinical variables. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00841802
Study type	Interventional
Source	Northwestern University
Contact
Status	Withdrawn
Phase	Phase 4
Start date	July 2008
Completion date	June 30, 2019

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT02071667` - Association of Periostin Levels and Chronic Sinusitis	N/A
Completed	`NCT01623310` - 12-Month OL Intranasal Fluticasone Propionate BID Using OptiNose Device	Phase 3
Completed	`NCT02024659` - Effects and Safety of Budesonide Inhalation Suspension Via Transnasal Nebulization in Nasal Polyps	Phase 2/Phase 3
Completed	`NCT00215787` - Investigation of the Association Between Nasal Polyposis and Extraesophageal Reflux Disease	N/A
Completed	`NCT04996576` - Infrazygomatic Versus Intranasal Injection Sphinopalatine Ganglion Blockade Effect on Surgical Field in FESS	N/A
Recruiting	`NCT03963648` - NO Measurements in Screening for Asthma and OSA, in Patients With CRSwNP	N/A
Recruiting	`NCT05094570` - Interleukin-4Ra Blockade by Dupilumab Decreases Staphylococcus Colonization and Increases Microbial Diversity in CRSwNP	Phase 4
Recruiting	`NCT05009758` - Moving Towards Precision Medicine in United Airways Disease: Unraveling Inflammatory Patterns in Asthmatic Patients With or Without Nasal Polyps	N/A
Completed	`NCT00731185` - Mometasone Furoate Nasal Spray for Treatment of Nasal Polyposis After Surgery (Study P03218)	Phase 3
Active, not recruiting	`NCT03943121` - The Effects of Steroid-eluting Stent Implant for the Treatment of Eosinophilic Chronic Rhinosinusitis With Nasal Polyps	N/A
Active, not recruiting	`NCT03704415` - Aggravated Airway Inflammation: Research on Genomics and Optimal Operative Treatment (AirGOs Operative)	N/A
Not yet recruiting	`NCT06070311` - Wound Healing After Endoscopic Sinus Surgery	N/A
Completed	`NCT02879929` - Development and Validity of the DyNaChron Questionnaire for Chronic Nasal Dysfunction	N/A
Recruiting	`NCT05672030` - Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP
Suspended	`NCT04261582` - Genetics and Genomics of Aspirin Exacerbated Respiratory Disease (AERD)
Recruiting	`NCT05063981` - Treatment With Mepolizumab on Patients With Severe Refractory Eosinophilic Asthma With or Without CRSwNP.
Completed	`NCT05180357` - RANS. Study in Patients With Severe Eosinophilic Asthma and Nasal Polyps.
Completed	`NCT00788463` - A Comparison of Beclomethasone Aqueous Spray and Aerosol Delivery Systems in Nasal Polyps	Phase 2
Completed	`NCT01198912` - Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial	Phase 2
Completed	`NCT03280537` - A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps	Phase 3