Nail Psoriasis Clinical Trial
Official title:
A Clinical Observation on the Efficacy and Safety of Pulsed Dye Laser (PDL) in the Treatment of Nail Psoriasis: a Single-blind, Randomized, Self-controlled Trial
1. Psoriasis is a common chronic, inflammatory disease characterized by skin changes and
joint involvement. About 50% of patients with psoriasis have damage to the nail,
especially in pustular psoriasis in the continuous acromegaly dermatitis. Common damage
includes pitting, uneven and tarnish of the deck, as well as the occurrence of nail
ridges, furrows, turbidity, hypertrophy, free ends and nail bed stripping, and even the
whole deck deformity or absence, etc., seriously affecting patients' social interaction
and mental health. Pathologically, telangiectasis is associated with the superficial and
middle layers of the dermis. Previous treatment of psoriasis nail is mainly topical
drugs (such as glucocorticoid, etc.), but due to its long disease period, topical drugs
are difficult to transdermal absorption, and the curative effect of skin lesions is
poor.
2. Pulsed dye laser (PDL) is effective for vasodilatory diseases, especially for the
superficial to middle layers of the dermis
3. It has been reported that PDL is effective in the treatment of psoriasis vulgis by
blocking the nutrient supply vessels of the lesions, improving the surrounding
microenvironment, reducing the number of cytotoxic T cells and helper T cells in the
dermis, and promoting the normalization of epidermal proliferation and differentiation.
4. Halometasone is a potent halogen - containing topical glucocorticoid. Have stronger
fight inflammation, fight allergy, contractive hemal, reduce hemal to connect the action
of permeability and fight hyperplasia Vaseline belongs to a kind of mineral wax, without
irritant, not easy to deteriorate, can let skin surface form a protective film when used
on the skin, let the moisture of the skin be evaporated not easily, have better protect
wet effect.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT03209388 -
Study of the Efficacy and Safety of Topical P-3073 in the Treatment of Mild to Moderate Psoriatic Fingernail/s
|
Phase 3 | |
Completed |
NCT00999687 -
Evaluation of the Efficacy and Safety of Indigo Naturalis Oil Extract on Psoriatic Nails
|
Phase 2/Phase 3 | |
Completed |
NCT00581100 -
Effects of Etanercept on Nail Psoriasis and Plaque Psoriasis
|
Phase 4 | |
Completed |
NCT04580537 -
Assessing the Efficacy of Image-guided Laser-assisted Enstilar® Delivery for Treatment of Psoriatic Nails
|
Phase 2 | |
Not yet recruiting |
NCT03263624 -
Efficacy of Combined Fractional Carbon Dioxide Laser and Topical Tazarotene in the Treatment of Psoriatic Nail Disease
|
Phase 4 | |
Completed |
NCT02606760 -
Study to Evaluate the Efficacy and Safety of P-3073 Nail Solution in the Treatment of Nails Affected by Psoriasis
|
Phase 3 | |
Completed |
NCT04227288 -
A Study Evaluating the Efficacy and Tolerability of Enstilar Foam in Patients With Nail Psoriasis
|
Phase 4 | |
Withdrawn |
NCT03079973 -
Study to Evaluate the Efficacy and Safety of P-3073 Nail Solution in the Treatment of Mild to Moderate Psoriatic Fingernail/s
|
Phase 3 | |
Completed |
NCT04380597 -
Observational Study in Patients With Nail Psoriasis Treated With Enstilar® to Assess the Severity Change and the Quality of Life
|
||
Completed |
NCT03991936 -
Benefit of Placebo and Different Concentrations of Triamcinolone Acetonide in Nail Psoriasis
|
Phase 4 | |
Recruiting |
NCT05124080 -
An Investigator Initiated Open Label Study Evaluating the Efficacy and Tolerability of Oral Deucravacitinib for the Treatment of Nail Psoriasis
|
Early Phase 1 | |
Completed |
NCT03757364 -
Methotrexate in the Treatment of Distal Interphalangeal Joint Extensor Tendon Enthesopathy in Nail Psoriasis
|
||
Completed |
NCT02016482 -
A Study to Evaluate the Safety and Efficacy of Adalimumab in Subjects With Chronic Plaque Psoriasis and Nail Psoriasis
|
Phase 3 | |
Completed |
NCT02168933 -
308nm Excimer Laser for Treatment of Fingernail Psoriasis
|
N/A | |
Completed |
NCT01445886 -
Comparison of Indigo Naturalis Oil Extract and Calcipotriol Solution in Treating Psoriasis
|
Phase 2/Phase 3 | |
Not yet recruiting |
NCT05695833 -
Nd:YAG Laser and Radiofrequency in Treatment of Fingernail Psoriasis
|
N/A | |
Completed |
NCT03616561 -
Quality of Life and Ultrasonographic Assessment of Nail Psoriasis After Treatment With Apremilast (JUST Study)
|
||
Completed |
NCT02235480 -
Efficacy and Safety of Tazarotene Gel in Nail Psoriasis
|
Phase 2 | |
Not yet recruiting |
NCT06150794 -
Methotrexate Alone vs Combination With Excimer Light in Nail Psoriasis
|
N/A | |
Active, not recruiting |
NCT05072886 -
Study of Efficacy and Safety of Investigational Treatment in Patients With Nail Psoriasis
|
Phase 1 |