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Nail Psoriasis clinical trials

View clinical trials related to Nail Psoriasis.

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NCT ID: NCT06150794 Not yet recruiting - Nail Psoriasis Clinical Trials

Methotrexate Alone vs Combination With Excimer Light in Nail Psoriasis

Start date: December 1, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to compare the efficacy of excimer laser in combination with intralesional MTX injection to intralesional MTX injection alone in treating nail psoriasis

NCT ID: NCT05695833 Not yet recruiting - Nail Psoriasis Clinical Trials

Nd:YAG Laser and Radiofrequency in Treatment of Fingernail Psoriasis

Start date: January 20, 2023
Phase: N/A
Study type: Interventional

Compare the effect of Radiofrequency to long pulsed Nd:YAG 1064 nm laser in treatment of fingernail psoriasis.

NCT ID: NCT05124080 Recruiting - Nail Psoriasis Clinical Trials

An Investigator Initiated Open Label Study Evaluating the Efficacy and Tolerability of Oral Deucravacitinib for the Treatment of Nail Psoriasis

Start date: March 1, 2024
Phase: Early Phase 1
Study type: Interventional

. An open label proof of concept study will be conducted to assess the efficacy and safety of deucravactinib for treatment of nail psoriasis. Twenty adult patients with nail psorasis and skin disease qualifying for a systemic agent per investigator will be treated with deucravacitinib 6 mg daily. Subjects will be assessed for a total of 48 weeks. Psoriasis assessments such as the modified Nail Psoriasis Severity Index will be conducted. Photos will be used to document nail involvement. Descriptive statistical analysis will be conducted at the conclusion of the study.

NCT ID: NCT05072886 Active, not recruiting - Plaque Psoriasis Clinical Trials

Study of Efficacy and Safety of Investigational Treatment in Patients With Nail Psoriasis

Start date: April 1, 2022
Phase: Phase 1
Study type: Interventional

Part 1 is a randomized, double-blind, placebo-controlled phase 1b study to evaluate AT193 in approximately 34 patients with nail psoriasis for 16 weeks. Part 2 is an open-label extension phase where all patients will receive active drug for an additional 16 weeks followed by a 2 week nontreatment period.

NCT ID: NCT04580537 Completed - Nail Psoriasis Clinical Trials

Assessing the Efficacy of Image-guided Laser-assisted Enstilar® Delivery for Treatment of Psoriatic Nails

LAsED
Start date: October 2, 2020
Phase: Phase 2
Study type: Interventional

The trial is conducted to investigate the clinical efficacy of a combination product containing calcipotriol and betamethasone formulated as an aerosol foam (Enstilar ©) for the treatment of nail psoriasis in conjunction with physical pre-treatment using a fractionally ablative carbon dioxide laser (AFL). It is hypothesized, based on preclinical data and comparable clinical trials, that laser processing prior to topical administration will lead to increased drug distribution, and thereby increase the efficacy of Enstilar® in treating nail psoriasis.

NCT ID: NCT04380597 Completed - Nail Psoriasis Clinical Trials

Observational Study in Patients With Nail Psoriasis Treated With Enstilar® to Assess the Severity Change and the Quality of Life

ENUPS
Start date: March 26, 2019
Phase:
Study type: Observational

Observational, prospective and multicentre study to evaluate the effectiveness of calcipotriene and betamethasone dipropionate aerosol foam (Cal / BD), prescribed according to clinical practice and following the Product Data Sheet instructions, in the topical treatment of nail psoriasis according to the change in the score of the Nail Psoriasis Severity Index (NAPSI) at 12 weeks of treatment with respect to the initial score.

NCT ID: NCT04227288 Completed - Nail Psoriasis Clinical Trials

A Study Evaluating the Efficacy and Tolerability of Enstilar Foam in Patients With Nail Psoriasis

Start date: November 1, 2021
Phase: Phase 4
Study type: Interventional

The aim of the proposed study is to evaluate the efficacy and safety of Enstilar Foam (calcipotriene and betamethasone dipropionate) for the treatment of nail psoriasis.

NCT ID: NCT03991936 Completed - Nail Psoriasis Clinical Trials

Benefit of Placebo and Different Concentrations of Triamcinolone Acetonide in Nail Psoriasis

Start date: March 11, 2020
Phase: Phase 4
Study type: Interventional

This purpose of this study is to determine the lowest effective concentration of intralesional triamcinolone acetonide in the treatment of nail psoriasis.

NCT ID: NCT03946826 Completed - Nail Psoriasis Clinical Trials

A Clinical Observation on the Efficacy and Safety of Pulsed Dye Laser (PDL) in the Treatment of Nail Psoriasis

Start date: August 1, 2015
Phase: N/A
Study type: Interventional

1. Psoriasis is a common chronic, inflammatory disease characterized by skin changes and joint involvement. About 50% of patients with psoriasis have damage to the nail, especially in pustular psoriasis in the continuous acromegaly dermatitis. Common damage includes pitting, uneven and tarnish of the deck, as well as the occurrence of nail ridges, furrows, turbidity, hypertrophy, free ends and nail bed stripping, and even the whole deck deformity or absence, etc., seriously affecting patients' social interaction and mental health. Pathologically, telangiectasis is associated with the superficial and middle layers of the dermis. Previous treatment of psoriasis nail is mainly topical drugs (such as glucocorticoid, etc.), but due to its long disease period, topical drugs are difficult to transdermal absorption, and the curative effect of skin lesions is poor. 2. Pulsed dye laser (PDL) is effective for vasodilatory diseases, especially for the superficial to middle layers of the dermis 3. It has been reported that PDL is effective in the treatment of psoriasis vulgis by blocking the nutrient supply vessels of the lesions, improving the surrounding microenvironment, reducing the number of cytotoxic T cells and helper T cells in the dermis, and promoting the normalization of epidermal proliferation and differentiation. 4. Halometasone is a potent halogen - containing topical glucocorticoid. Have stronger fight inflammation, fight allergy, contractive hemal, reduce hemal to connect the action of permeability and fight hyperplasia Vaseline belongs to a kind of mineral wax, without irritant, not easy to deteriorate, can let skin surface form a protective film when used on the skin, let the moisture of the skin be evaporated not easily, have better protect wet effect.

NCT ID: NCT03757364 Completed - Nail Psoriasis Clinical Trials

Methotrexate in the Treatment of Distal Interphalangeal Joint Extensor Tendon Enthesopathy in Nail Psoriasis

Start date: January 7, 2018
Phase:
Study type: Observational

The primary aim of the study is to assess the effect of methotrexate on the development of distal interphalangeal joint extensor tendon enthesopathy.