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Defining Circadian Metabolism in Non-alcoholic Fatty Liver Disease — DECIMAL  

NAFLD Clinical Trial

Official title:
Defining Circadian Metabolism in Non-alcoholic Fatty Liver Disease

Clinical Trial Summary

The investigators will conduct an open label, experimental medicine study exploring the diurnal patterns of hepatic lipid metabolism in NAFLD and non-NAFLD participants (determined by Transient elastography (TE) with controlled attenuation parameter (CAP)). We will also determine whether the diurnal patterns of lipid metabolism in NAFLD participants can be modified using lifestyle and weight loss intervention. Fourteen participants without NAFLD will have morning and evening metabolic investigations (visit 1M & 1E) to assess for changes in lipid flux pathways across the course of the day. After morning and evening investigations their involvement in the clinical study will then end. Seventeen NAFLD participants will also have identical baseline morning and evening investigation after which they will be enrolled into a 12-week lifestyle and weight loss programme. After 12-weeks, all 17 participants with NAFLD will have a follow up CAP, and morning and evening metabolic investigations (visit 2M & 2E).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05962099
Study type Observational
Source University of Oxford
Contact Jeremy Tomlinson
Phone 01865 857359
Email jeremy.tomlinson@ocdem.ox.ac.uk
Status Recruiting
Phase
Start date March 1, 2021
Completion date June 1, 2024
View Details
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