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Efficacy of N-Acetylcysteine in Improving/Normalizing ALT & AST in Patients of NAFLD

NAFLD Clinical Trial

Official title:
Efficacy of N-Acetylcysteine in Improving/Normalizing ALT & AST in Patients of NAFLD

Clinical Trial Summary

Currently researches are focusing on the effect of antioxidants in the treatment of non-alcoholic fatty liver disease (NAFLD). Since N-acetyl cysteine (NAC) has been proven to have antioxidant and anti-inflammatory properties, therefore, we will conduct this study to determine the effect of NAC in patients of NAFLD with raised liver enzymes.

Clinical Trial Description

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing globally, and presents a challenge for the medical community since it has no FDA approved treatment. An important feature of non-alcoholic fatty liver disease (NAFLD) is hepatic steatosis leading to hepatic dysfunction . It has been reported that NAFLD patients with increased liver enzymes have a greater risk of developing complications like cirrhosis and end-stage liver disease. since N-acetyl cysteine (NAC) has been proven to have antioxidant and anti-inflammatory properties, therefore, we will conduct this study to determine the effect of NAC in patients of NAFLD with raised liver enzymes (ALT, AST). Patients presenting with ultrasound showing fatty liver with raised liver enzymes will be recruited. They will be randomized into two groups (group A and group B). The odd number patients will be allocated group A and even number patients will be allocated to group B. Group A: patients in this group will be advised to follow a diet plan & daily 20 minutes brisk walking. Group B: Patients in this group will be given NAC 200mg BD along with diet plan & exercise. This drug will be provided to the patients by the investigators free of cost. The liver function tests and side effects of NAC will be followed at 12 weeks . ;

Study Design

Related Conditions & MeSH terms

  • NAFLD
  • Non-alcoholic Fatty Liver Disease
Clinical Trial Details
NCT number NCT05576428
Study type Interventional
Source Dow University of Health Sciences
Contact
Status Not yet recruiting
Phase N/A
Start date November 1, 2022
Completion date May 15, 2023
View Details
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