Myxoid Liposarcoma Clinical Trial
Official title:
International Prospective Registry on Local Treatment Approaches in Myxoid Liposarcomas
To prospectively study commonly used local treatment approaches in Myxoid Liposarcoma (MLS)
Status | Recruiting |
Enrollment | 300 |
Est. completion date | January 2031 |
Est. primary completion date | January 2031 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Age > 18 years - Biopsy proven MLS, including the reciprocal chromosomal translocation t(12;16)(q13;p11) - ECOG PS 0-2 - Written informed consent to share coded information in this international Registry Exclusion Criteria: - Prior radiotherapy to the target area - Pregnancy |
Country | Name | City | State |
---|---|---|---|
Netherlands | The Netherlands Cancer Institute | Amsterdam |
Lead Sponsor | Collaborator |
---|---|
The Netherlands Cancer Institute | Aarhus University Hospital, ANZSA (Australia and New Zealand Sarcoma Association), Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Haukeland University Hospital, Institut Curie, Institute for Cancer Research and treatment, Leiden University Medical Center, M.D. Anderson Cancer Center, Maastro Clinic, The Netherlands, Mayo Clinic, MOUNT SINAI HOSPITAL, National Cancer Center, Japan, Princess Margaret Hospital, Canada, Radboud UMC, Universitäts-Frauenklinik Graz, Universitetssykehus, University Hospital Heidelberg, University Hospital, Antwerp, University Medical Center Groningen, University of Sydney, Vienna General Hospital |
Netherlands,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Patient-Reported Outcome Measures (PROMs) | PRO-CTCAE Item Library; relevant questions from the Patient-Reported Outcomes version of the CTCAE (PRO-CTCAE) | From baseline visit to the end of 5 years of follow-up | |
Other | Health-Related Quality of Life (HRQoL) | EORTC QLQ-C30; 30-item HRQoL questionnaire; EORTC Items Library; 3 questions to assess some radiotherapy-specific HRQoL; EQ5D-5L; descriptive system for measurement of health; iMCQ; relevant items from the Medical Consumption Questionnaire (iMCQ) to assess medical consumption; PRODISQ; PROductivity and DISease Questionnaire to assess all relevant aspects of the relationship between health and productivity; | From baseline visit to the end of 5 years of follow-up | |
Primary | Local recurrence free survival | Survival from surgery to local recurrence (event) or last follow-up | From surgery to the end of at least 5 years of follow-up | |
Secondary | Wound complications | Any wound complication requiring intervention | From surgery to 6 months of follow-up | |
Secondary | Late toxicity | Any grade =2 late (radiation-induced) toxicity according to CTCAE v5.0 toxicity criteria | From 3 months after surgery to the end of at least 5 years of follow-up |
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT01957709 -
Recombinant Interferon Gamma in Treating Patients With Soft Tissue Sarcoma
|
Early Phase 1 | |
Active, not recruiting |
NCT03600649 -
Clinical Trial of SP-2577 (Seclidemstat) in Patients With Relapsed or Refractory Ewing or Ewing-related Sarcomas
|
Phase 1 | |
Completed |
NCT02821507 -
Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma
|
Phase 2 | |
Withdrawn |
NCT03397186 -
Immune Changes Following Trabectedin in Patients With Metastatic or Unresectable Sarcoma
|
Phase 2 | |
Active, not recruiting |
NCT03989596 -
Hypofractionated Radiotherapy With Hyperthermia in Unresectable or Marginally Resectable Soft Tissue Sarcomas
|
Phase 2 | |
Enrolling by invitation |
NCT05266196 -
A Rollover Protocol to Allow for Continued Access to the LSD1 Inhibitor Seclidemstat (SP-2577)
|
Phase 1/Phase 2 | |
Recruiting |
NCT05492682 -
START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer
|
Phase 1 | |
Active, not recruiting |
NCT03651375 -
Hypofractionated Radiotherapy With Sequential Chemotherapy in Marginally Resectable Soft Tissue Sarcomas of Extremities or Trunk Wall
|
Phase 2 | |
Active, not recruiting |
NCT00633165 -
Brostallicin Clinical Trial for Myxoid Liposarcoma
|
Phase 2 | |
Recruiting |
NCT04044768 -
Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
|
Phase 2 | |
Active, not recruiting |
NCT03816475 -
Hypofractionated Radiotherapy in Locally Advanced Myxoid Liposarcomas of Extremities or Trunk Wall (LIPO-MYX Trial)
|
Phase 2 |