Myositis Clinical Trial
Official title:
Comparison of Magnetic Resonance (MR) Imaging Against Clinical Criteria in the Diagnosis and Monitoring of Adult Idiopathic Myopathy
A prospective observational study to determine the effectiveness of magnetic resonance (MR) imaging in the diagnosis and monitoring of idiopathic myopathy in adult humans.
Idiopathic inflammatory myopathies are a heterogeneous group of conditions characterised by
skeletal muscle inflammation leading to proximal muscle weakness, often with tenderness, and
occasionally dermatological manifestations. Diagnosis is clinical and is based on the Bohan
and Peter criteria which comprises clinical examination, serological markers,
electromyography (EMG) and muscle biopsy. This has relatively poor sensitivity and
specificity. Muscle biopsy in particular has a false negative rate of 10-15% and is
invasive. Clinical criteria also lack the discriminatory power to differentiate between
recurrent (or breakthrough) myopathy and myopathy secondary to treatment with
corticosteroid.
Magnetic resonance (MR) imaging has the advantage of being non-invasive, and is able to
discriminate between different tissues, and to identify areas of inflammation. The aim of
this study is to assess the effectiveness of MR sequences in the diagnosis of myopathy,
monitoring of treatment response, and in differentiating between breakthrough myopathy and
steroid-induced myopathy.
;
Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT06300983 -
Effectiveness of a Psychoeducational Intervention on Myositis Patients' Quality of Life and Well-Being
|
N/A | |
| Recruiting |
NCT05832034 -
Add-on Intravenous Immunoglobulins in Early Myositis
|
Phase 2 | |
| Recruiting |
NCT05979441 -
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy
|
Phase 3 | |
| Active, not recruiting |
NCT02468895 -
MYOPROSP - a Prospective Cohort Study in Myositis
|
||
| Recruiting |
NCT01501019 -
Exercise in Sjogren, Myositis and Takayasu's Arteritis
|
N/A | |
| Recruiting |
NCT05523167 -
A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy.
|
Phase 2/Phase 3 | |
| Completed |
NCT03414086 -
Predictor of Clinical Response to Acthar in Myositis
|
||
| Terminated |
NCT03937856 -
Smartphone Mindfulness Meditation for Patients With Rheumatic Diseases
|
N/A | |
| Completed |
NCT03440034 -
Study of Pioglitazone in Sporadic Inclusion Body Myositis
|
Phase 1 | |
| Recruiting |
NCT05895786 -
A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]
|
Phase 3 | |
| Completed |
NCT00001331 -
Genetic and Family Studies of Inherited Muscle Diseases
|
N/A | |
| Not yet recruiting |
NCT06284954 -
A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis
|
Phase 2 | |
| Terminated |
NCT04309227 -
Comparison of Training Load With/Out Blood Flow Restriction Training in Rheumatoid Populations
|
N/A | |
| Completed |
NCT03059394 -
Validation of Rehab Assessments in Myositis Patients
|
N/A | |
| Completed |
NCT00106184 -
Rituximab for the Treatment of Refractory Adult and Juvenile Dermatomyositis (DM) and Adult Polymyositis (PM)
|
Phase 2 | |
| Recruiting |
NCT04367350 -
Prospective Registry of Corona Virus Disease 2019 (Covid-19) Patients With Neuromuscular Involvement
|
||
| Completed |
NCT01734369 -
Environmental Risk Factors for Myositis in Military Personnel
|
||
| Recruiting |
NCT02450396 -
Pregnancy and Medically Assisted Conception in Rare Diseases
|
||
| Recruiting |
NCT03912428 -
Novel PET Radioligands as Inflammatory Biomarkers in Rheumatoid Arthritis and Myositis
|
Phase 1 | |
| Active, not recruiting |
NCT03215927 -
Abatacept for the Treatment of Myositis-associated Interstitial Lung Disease
|
Phase 2 |