Myopia Clinical Trial - Effect of Axial Length of the Globe on Retinal

Status Not yet recruiting

Clinical Trial Summary

the goal of this obsrevational study is to learn about retinal nerve fibres and if their numbers changed with axial length of the globe or not. the main question to answer is there is effect of long axial length on the thickness of the retinal nerve fibers participants will be asked to: - measure the axial length with ultrasound - measure the thickness of retinal nerve fibers with optical coherence tomography

Clinical Trial Description

Aim of the work: To investigate the effect of axial length on the peripapillary retinal nerve fiber layer. Patients and methods Study design: Cross sectional comparative study. Location: Ophthalmology department, Sohag teaching hospital. Ethical approval: A written informed consent will be taken from all patients about the aim of the study, the nature of the planned investigation. An approval of the ethical committee of Sohag Faculty of Medicine will be fulfilled. Methodology The study will include 80 patients healthy volunteers who underwent ophthalmologic examinations including retinal nerve fiber layer (RNFL) thickness analysis with optical coherence tomography (OCT), auto refraction, and axial length measurement. Inclusion criteria: Healthy volunteers attending the outpatient clinic for surface ocular diseases. Exclusion criteria: - Glaucoma patients. - Media opacity (corneal, lens or vitreous opacity) - Previous ocular surgery. - Diabetic patients. - Retinal diseases. Method of the study: 1. Detailed ophthalmological and medical history. 2. Detailed slit lamp examination. 3. Visual acuity (VA) and best corrected visual acuity (BCVA) using Snellen chart and recorded in decimal notation. 4. Auto refraction using Topcon auto refractometer RM-800. 5. Optical coherence tomography (OCT) scan of retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness using Avanti scanner Optovue. 6. Axial length (AL) measured by E-Z scan 5500 sonomed A-scan ultrasound and biometry. The patients will be divided into 3 groups: Group 1 patients with axial length less than 21 mm. Group 2 patients with axial length 21-24 mm. Group 3 patients with axial length more than 24 mm. ;

Study Design

Related Conditions & MeSH terms

Myopia

Clinical Trial Details

NCT number	NCT05716776
Study type	Observational
Source	Sohag University
Contact	Asmaa I Mostafa
Phone	01098794745
Email	asmaaelmalah8@gmail.com
Status	Not yet recruiting
Phase
Start date	February 2023
Completion date	January 2024

View Details

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Effect of Axial Length of the Globe on Retinal Nerve Fibre Thickness

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms