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Lacritin and Heparanase Levels in Human Tears After Laser Refractive Surgery

Myopia Clinical Trial

Official title:
Lacritin and Heparanase Levels in Human Tears After Laser Refractive Surgery

Clinical Trial Summary

The purpose of this study is to measure tear lacritin and heparanase levels before and following surgery using a minimal risk procedure to collect tears from patients undergoing PRK or LASIK.

Clinical Trial Description

Lacritin is a naturally occurring tear protein with antimicrobial activity that is capable of stimulating mitogenesis in human corneal epithelial cells and promoting production of tears in lacrimal gland acinar cells. A recently developed immunoassay for lacritin may help characterize the lacritin response following refractive surgery with the possible development of recombinant lacritin as a novel therapeutic agent for wound healing. Heparanase (HPSE) acts as a regulator for lacritin by cleaving heparan sulfate chains and allowing lacritin to bind. We aim to measure both tear lacritin and HPSE pre- and post-operatively to elucidate lacritin and HPSE's response in patients undergoing PRK (photorefractive keratectomy) and LASIK (Laser-assisted in situ keratomileusis) at the Walter Reed Center for Refractive Surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01049724
Study type Observational
Source Fort Belvoir Community Hospital
Contact
Status Completed
Phase N/A
Start date January 2010
Completion date November 2017
View Details
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