Muscle Characteristics Associated With Statin Therapy

Status Withdrawn

Clinical Trial Summary

The purpose of this study is to investigate the mechanism of statin-related myopathy by evaluating muscle samples before and after statin exposure.

Clinical Trial Description

Statins have been proven to reduce cardiovascular events and mortality in large clinical trials but remain underutilized partly due to the associated myopathy. Severe reactions manifested as rhabdomyolysis are rare but myalgia is commonly noted in clinical practice. The pathophysiology of these events remains obscure. Previous studies suggest that statins block the downstream products (such as cellular signaling molecules) of the mevalonate pathway needed for normal muscle function. Other studies show that statins are associated with gene expressions involved in muscle damage such as atrogin-1. We will quantify these entities pre and post statin therapy to better understand these reactions. ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Myopathy

Clinical Trial Details

NCT number	NCT00990834
Study type	Interventional
Source	Scripps Health
Contact
Status	Withdrawn
Phase	N/A
Start date	November 2009
Completion date	June 2011

View Details

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