Myoma Clinical Trial
Official title:
Effect of Magnesium Sulphate on Postoperative Coagulation as Measured by Thromboelastography
Arterial and venous thrombotic events are the clinical manifestation of postoperative hypercoagulability. Altered serum magnesium may play a role in the balance of coagulation. In this study, the investigators investigated the effect of magnesium sulphate on the postoperative coagulation change in total intravenous anesthesia (TIVA).
Status | Completed |
Enrollment | 40 |
Est. completion date | October 2010 |
Est. primary completion date | October 2010 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 20 Years to 60 Years |
Eligibility |
Inclusion Criteria: - ASA ?-? patients undergoing pelviscopic gynecologic operation under general anesthesia. Exclusion Criteria: - Pregnancy - Previous known hematologic disorder - Recent medication interfering with hemostasis - Severe anemia - Liver disease - Cardiovascular or respiratory disease |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do |
Lead Sponsor | Collaborator |
---|---|
Seoul National University Bundang Hospital |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | thromboelastography (TEG) analysis | 10 minutes before the induction of anesthesia 10 minutes after the recovery from the anesthesia |
twice | No |
Secondary | hemoglobin level | 10 minutes before the induction of anesthesia 10 minutes after the recovery from the anesthesia |
twice | No |
Secondary | platelet count | 10 minutes before the induction of anesthesia 10 minutes after the recovery from the anesthesia |
twice | No |
Secondary | international normalized ratio of prothrombin time (INR-PT) | 10 minutes before the induction of anesthesia 10 minutes after the recovery from the anesthesia |
twice | No |
Secondary | activated partial thromboplastin time (aPTT) | 10 minutes before the induction of anesthesia 10 minutes after the recovery from the anesthesia |
tiwce | No |
Secondary | serum magnesium level | 10 minutes before the induction of anesthesia 10 minutes after the recovery from the anesthesia |
twice | No |
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