Effect of Heart Rate on Left Ventricular Performance

Myocardial Function Clinical Trial

Official title: Effect of Heart Rate on Left Ventricular Performance

Status Recruiting

Clinical Trial Summary

The current study is aimed at determining the normal response to increasing heart rates. For this purpose, atrial pacing will be used to increase heart rate.

Clinical Trial Description

Participants will be patients with pacemakers and normal A-V node conduction with a possibility for right atrial pacing mode.

Detailed Echo studies will be performed at baseline. Echo studies will be repeated at each pacing stage, stages defined as 10 bpm increments in paced heart rate. Each stage will last 2-3 min or as long as it takes to record the echo study. Heart rate will be increased to 85% of predicted heart rate for age or at to appearance of signs of ischemia.

Hemodynamic parameters will be recorded and segmental longitudinal strain will be calculated (as well as other Echo data), for each stage. ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Myocardial Function
• Myocardial Strain

• NCT number: NCT01112176
• Study type: Interventional
• Source: Hillel Yaffe Medical Center
• Contact: David S. Blondheim, MD
• Phone: 97246304488
• Email: davidb@hy.health.gov.il
• Status: Recruiting
• Phase: N/A
• Start date: April 2010
• Completion date: April 2012