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Myocardial Haemorrhage clinical trials

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NCT ID: NCT03523624 Completed - Clinical trials for ST-Elevation Myocardial Infarction

Factor XIII and Other Biomarkers in ST Segment Elevation Myocardial Infarction

eXIST
Start date: November 1, 2015
Phase:
Study type: Observational

In medical practice, a combination of clinical exam, electrocardiograms, circulating biomarkers, and imaging is used to gain insights on the prognosis after myocardial infarction. Novel molecular non-invasive tools are needed that help clinicians overcome the adverse events of post-myocardial infarction remodelling and thereby achieve improved therapy for its prevention. Coagulation factor XIII (FXIII) decay has been linked to major adverse cardiac events (MACE) in patients with acute coronary syndromes. Given the correlation between both intramyocardial haemorrhage and microvascular damage with acute phase complications in ST-elevation myocardial infarction, we hypothesise that excessive FXIII decay within the first week may predict acute phase outcomes in these patients. If this holds true, FXIII determination could be used as diagnostic and prognostic tool.