Myocardial Dysfunction Clinical Trial
Official title:
Detection of Early Changes in Left Ventricular Function by Myocardial Deformation Imaging After Acute Excessive Alcohol Ingestion
Background: Chronic excessive alcohol consumption leads to progressive and chronic cardiac
dysfunction. In general, patients consuming alcohol more than five years are at risk for the
development of dilated cardiomyopathy. As only few data about immediate changes in left
ventricular function after acute excessive alcohol ingestion are available, this study
sought to close this gap.
Methods: 200 subjects (not used to alcohol, no cardiac disease) will be examined up to 12
hours after alcohol excess and after 4 weeks of complete alcohol abstinence.
Echocardiography will performed at baseline and at follow-up regarding conventional
parameter [as left ventricular ejection fraction (LVEF), transmitral early (E) and late (A)
Doppler flow velocities, E/A ratio, deceleration time of E (DT) and isovolumic relaxation
time (IVRT)] and myocardial deformation data [as layer specific global circumferential (endo
GCS, mid GCS, epi GCS) and longitudinal (endo GLS, mid GLS, epi GLS) strain].
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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