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Clinical Trial Summary

This is a Phase II study of allogeneic hematopoietic stem cell transplant (HCT) using a myeloablative preparative regimen (of either total body irradiation (TBI); or, fludarabine/busulfan for patients unable to receive further radiation). followed by a post-transplant graft-versus-host disease (GVHD) prophylaxis regimen of post-transplant cyclophosphamide (PTCy), tacrolimus (Tac), and mycophenolate mofetil (MMF).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Acquired Bone Marrow Failure Syndromes
  • Acute Leukemia
  • Acute Lymphoblastic Leukemia
  • Acute Myeloid Leukemia
  • Anemia
  • Biphenotypic/Undifferentiated/Prolymphocytic Leukemias
  • Bone Marrow Failure Disorders
  • Burkitt Lymphoma
  • Chronic Lymphocytic Leukemia
  • Chronic Myelogenous Leukemia
  • Diffuse Large Cell Non Hodgkins Lymphoma
  • Follicular Lymphoma
  • High Grade Non-Hodgkin's Lymphoma, Adult
  • High Risk Anemia
  • Juvenile Myelomonocytic Leukemia
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Leukemia, Myeloid
  • Leukemia, Myelomonocytic, Juvenile
  • Leukemia, Plasma Cell
  • Leukemia, Prolymphocytic
  • Lymphoblastic Lymphoma
  • Lymphoma
  • Lymphoma, B-Cell, Marginal Zone
  • Lymphoma, Mantle-Cell
  • Lymphoma, Non-Hodgkin
  • Lymphoplasmacytic Lymphoma
  • Mantle-Cell Lymphoma
  • Marginal Zone B-Cell Lymphoma
  • MRD Positive Leukemia
  • Multiple Myeloma
  • Myelodysplasia
  • Myelofibrosis
  • Myeloproliferative Disorders
  • Myeloproliferative Neoplasms
  • Natural Killer Cell Malignancies
  • Pancytopenia
  • Plasma Cell Leukemia
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Prolymphocytic Leukemia
  • Refractory Anemia
  • Small Lymphocytic Lymphoma
  • Waldenstrom Macroglobulinemia

NCT number NCT03314974
Study type Interventional
Source Masonic Cancer Center, University of Minnesota
Contact Tamy Grainger
Phone (612)-273-2800
Email tgraing1@fairview.org
Status Recruiting
Phase Phase 2
Start date March 30, 2018
Completion date November 10, 2025

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