Clinical Trials Logo
  1. Home
  2. Myelomeningocele
  3. NCT01208584

Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions

Myelomeningocele Clinical Trial

Official title:
Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions

Clinical Trial Summary

The purpose of this study is to use functional MRI (fMRI) and magnetic resonance (MR) diffusion tensor imaging (DTI) to investigate brain activation and white matter changes in patients with congenital (birth defect of the spinal column), acute and chronic complete spinal cord lesions. The findings of this study may provide a basis to better understand the pathomechanisms underlying the dynamic neurofunctional changes following a spinal cord lesions in man. This understanding is important for the improvement of existing therapies and for the development of new therapeutic approaches.

Clinical Trial Description

Recently new approaches to spinal cord repair have been successfully established in animal models. Promising therapies for promoting spinal axonal regeneration in man will be available in the near future. Most research in the field is focussed on the lesion itself and the perilesional spinal cord. The recovery of motor and sensory function is,however, not permitted by local processes at the spinal level only. The whole central nervous system (CNS) reacts to such a condition. Therefore the modulation of motor and sensory function in spinal cord lesioned patients should be reflected in characteristic changes of cortical brain activity, which are accessible to new non-invasive functional neuroimaging techniques such as functional magnetic resonance imaging (fMRI). Changes of white matter due to axonal damage can also be measured qualitatively and quantitatively using MR diffusion tensor imaging (DTI). Those measures may provide a basis to better understand the pathophysiology underlying spinal cord lesions in man, including changes in brain function over time (during rehabilitation) or related to specific treatment. However, there are no studies available yet addressing those topics or providing mechanism-based approaches for determining the time interval of application of novel neuroregenerative drugs. By investigation of brain activation and white matter changes in patients with congenital(myelomeningocele (MMC)), acute and chronic spinal cord lesions (ASIA A) first and fundamental work in this field will be conducted in this study. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01208584
Study type Observational
Source University Hospital, Basel, Switzerland
Contact
Status Completed
Phase Phase 4
Start date August 2008
Completion date October 2013
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06042140 - Cryopreserved Human Umbilical Cord as a Meningeal Patch in Fetoscopic Spina Bifida Repair N/A
Recruiting NCT03562286 - Open Spina Bifida Fetoscopic Repair Project N/A
Completed NCT04468568 - In Utero Repair of Myelomeningocele: Atosiban Versus Terbutaline
Recruiting NCT03856034 - Laparotomy Versus Percutaneous Endoscopic Correction of Myelomeningocele N/A
Recruiting NCT04362592 - In-Utero Endoscopic Correction of Spina Bifida N/A
Active, not recruiting NCT03936322 - Minimally Invasive Fetoscopic Regenerative Repair of Spina Bifida - A Pilot Study N/A
Not yet recruiting NCT06405698 - Role of Perforator Flaps in Back Defects Reconstruction N/A
Active, not recruiting NCT00175123 - Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele Phase 4
Completed NCT02390895 - Prenatal Endoscopic Repair of Fetal Spina Bifida N/A
Active, not recruiting NCT03090633 - Fetoscopic Repair of Isolated Fetal Spina Bifida N/A
Not yet recruiting NCT03088761 - Cuff Pressure in Infants N/A
Active, not recruiting NCT04484441 - Maternal-fetal Immune Responses to Fetal Surgery
Recruiting NCT04738539 - Efficacy of Contrast Enhanced Voiding Urosonography for Urodynamic Studies
Recruiting NCT04652908 - Cellular Therapy for In Utero Repair of Myelomeningocele - The CuRe Trial Phase 1/Phase 2
Terminated NCT02493062 - Evaluation of Hysterotomy Site After Open Fetal Surgery N/A
Completed NCT03550898 - Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele N/A
Active, not recruiting NCT04251806 - Sleep-disordered Breathing in Infants With Myelomeningocele
Terminated NCT02509377 - Fetal Myelomeningocele Repair With Maternal BMI Between 35.0 and 40.0 N/A
Recruiting NCT03788122 - Fetal Surgery Interview Study: Parental Perceptions of Fetal Surgery N/A
Completed NCT02664207 - Extended Criteria For Fetal Myelomeningocele Repair N/A